| dc.creator | Lascano, Elena C. | |
| dc.creator | Negroni, Jorge A. | |
| dc.date | 2006-03 | |
| dc.date | 2022-12-07T13:24:18Z | |
| dc.date.accessioned | 2023-07-15T09:03:19Z | |
| dc.date.available | 2023-07-15T09:03:19Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/146976 | |
| dc.identifier | https://pmr.safisiol.org.ar/wp-content/uploads/2022/09/vol1_n8_march.pdf | |
| dc.identifier | issn:1669-5410 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7486648 | |
| dc.description | In the normoperfused heart, Ca²⁺ enters the myocardial cell through voltagedependent Ca²⁺ channels and is extruded through the sarcolemmal Ca²⁺ pump and the Na+/Ca²⁺ exchanger. During ischemia and early reperfusion, however, sarcoplasmic reticulum reuptake and sarcolemmal Ca²⁺ pump activities are impaired due to decreased ATP. In addition, owing to defective Na⁺-K⁺ pump performance and low pH favoring Na⁺ entry in exchange for H⁺ output through the Na⁺/H⁺ exchanger, the Na⁺/Ca²⁺ exchanger operates in its reverse mode incorporating Ca²⁺ to diminish increased intracellular Na⁺.
Thus, the resulting impaired Ca²⁺ balance produces Ca²⁺ overload and myocardial injury probably by activation of Ca²⁺-dependent proteases which can partially destroy contractile proteins leading to decreased responsiveness of contractile filaments to Ca²⁺ (18). This chain of ischemic events is in part counteracted by activation of ATP-dependent K⁺ (KATP) channels which by allowing earlier passive K⁺ output, shortens action potential duration and reduces the time during which Ca²⁺ can enter the cell. | |
| dc.description | Sociedad Argentina de Fisiología | |
| dc.format | application/pdf | |
| dc.language | es | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Fisiología | |
| dc.subject | Ischemia | |
| dc.subject | Potassium | |
| dc.title | Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury | |
| dc.type | Articulo | |
| dc.type | Revision | |
