| dc.creator | Cingolani, Horacio Eugenio | |
| dc.creator | Ennis, Irene Lucía | |
| dc.date | 2005-10 | |
| dc.date | 2022-12-07T12:55:43Z | |
| dc.date.accessioned | 2023-07-15T09:03:14Z | |
| dc.date.available | 2023-07-15T09:03:14Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/146969 | |
| dc.identifier | https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n3_october.pdf | |
| dc.identifier | issn:1669-5410 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7486643 | |
| dc.description | The stretching of a papillary muscle induces a sudden and immediate rise in force, due to an augmentation in myofilament Ca²⁺ responsiveness. During the next 10 to 15 minutes a progressive increase in force develops known as the “slow force response” (SFR), that is due to a progressive increase in Ca²⁺ transient amplitude. The source for this increase in Ca²⁺ transient remained obscure until we proposed a link between Ca²⁺ influx mediated by Na⁺/ Ca²⁺ (NCX) exchange in reverse mode and the activation of the Na⁺/H⁺ exchanger (NHE-1) caused by stretch;1-4 being the increase in the Ca²⁺ transient secondary to the increase in intracellular Na⁺ concentration ([Na+]i). It is known that the increase in [Na⁺]i can induce an increase in intracellular Ca²⁺ levels ([Ca²⁺ ]i) through the NCX either as a result of a decrease in Ca²⁺ efflux (decreased forward mode) or an increase in Ca²⁺ entry (increased reverse mode). The fact that after myocardial stretch there is no increase in diastolic [Ca²⁺ ]i 1,5 as would be expected for a decrease in Ca²⁺ efflux, suggests that the reverse mode of NCX is the mechanism involved in the increase in Ca²⁺ transient.1The SFR, the increase in [Na⁺]i and the increase in Ca²⁺ transient can be abolished by blocking the Angiotensin II (Ang II) AT1 receptors with losartan; the endothelin (ET) ETA receptors by BQ123 and by inhibition of the NHE-1.6 | |
| dc.description | Sociedad Argentina de Fisiología | |
| dc.description | Facultad de Ciencias Médicas | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Fisiología | |
| dc.subject | Myocardial stretch | |
| dc.title | Na⁺/H⁺ exchanger and myocardial growth | |
| dc.type | Articulo | |
| dc.type | Revision | |
