| dc.creator | Camilión, María Cecilia | |
| dc.creator | Gende, Oscar Alfredo | |
| dc.creator | Cingolani, Horacio Eugenio | |
| dc.date | 1989 | |
| dc.date | 2022-10-20T16:17:07Z | |
| dc.date.accessioned | 2023-07-15T05:06:45Z | |
| dc.date.available | 2023-07-15T05:06:45Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/144179 | |
| dc.identifier | issn:0028-1298 | |
| dc.identifier | issn:1432-1912 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7472130 | |
| dc.description | The chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 ± 10 beats/min) was obtained at 3 × 10⁻⁶ mol/l. Reserpine pretreatment, or propranolol 3 × 10⁻⁷ mol/l, or propranolol plus prazosin 10⁻⁶ mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 × 10⁻⁵ mol/l plus cocaine 10⁻⁵ mol/1) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings. | |
| dc.description | Centro de Investigaciones Cardiovasculares | |
| dc.format | application/pdf | |
| dc.format | 452-455 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Bioquímica | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Bay K 8644 | |
| dc.subject | Norepinephrine release | |
| dc.subject | Chronotropic response | |
| dc.subject | Rat atria | |
| dc.title | Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine | |
| dc.type | Articulo | |
| dc.type | Articulo | |
