Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria

dc.creatorCamilión de Hurtado, María Cristina
dc.creatorGende, Oscar Alfredo
dc.creatorCingolani, Horacio Eugenio
dc.date1991-06
dc.date2022-12-14T17:11:11Z
dc.date.accessioned2023-07-15T05:02:23Z
dc.date.available2023-07-15T05:02:23Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/147269
dc.identifierissn:0028-1298
dc.identifierissn:1432-1912
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7471853
dc.descriptionThe effect of Bay K 8644 (a dihydropyridine Ca²⁺-channel activator), was examined on spontaneous and stimulus-evoked release of tritium from isolated rat atria prelabelled with [³H]-noradrenaline. Bay K8644 (3μmol/l) significantly increased atrial rate from 206±7 to 259±9 beats·min⁻¹ (P<0.05) and also tritium outflow (expressed as fractional rate of loss in min⁻¹ × 10³) from 6.49±0.35 to 8.61±0.74 (P<0.05). Neither the maximal rate nor the overflow of tritium induced by stimulation of sympathetic nerve terminals was changed by the compound. The increase in basal tritium outflow produced by Bay K 8644 was calcium-dependent. However, it could not be antagonized by nitrendipine. The overflow of tritium induced by Bay K 8644 consisted mainly of 3,4-dihydroxyphenylglycol ([³H]-DOPEG), indicating that the compound produces a leakage from the storage vesicles of sympathetic nerve terminals of the isolated rat atria.
dc.descriptionCentro de Investigaciones Cardiovasculares
dc.formatapplication/pdf
dc.format603-608
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.subjectMedicina
dc.subjectBay K 8644
dc.subjectRat atria
dc.subjectTritium effiux
dc.subjectAdrenergic nerve endings
dc.subject[³H]-noradrenaline
dc.titleBay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
dc.typeArticulo
dc.typeArticulo


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