| dc.creator | Gómez Dumm, César Leandro Alberto | |
| dc.creator | Rebolledo, Oscar Remigio | |
| dc.creator | Gagliardino, Juan José | |
| dc.date | 1979-09-02 | |
| dc.date | 2022-11-04T18:17:00Z | |
| dc.date.accessioned | 2023-07-15T05:00:45Z | |
| dc.date.available | 2023-07-15T05:00:45Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/145237 | |
| dc.identifier | issn:0302-766X | |
| dc.identifier | issn:1432-0878 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7471748 | |
| dc.description | The ultrastructural changes in pancreatic β cells were studied following glucose-induced insulin secretion in vitro, at two different extracellular pH (7.4 and 7.8). The pancreata perfused at pH 7.4 exhibited a biphasic insulin response to glucose challenge together with signs of increased emiocytotic activity and numerous microtubules in the β cells. Conversely, the pancreata perfused at pH 7.8 showed a significant decrease in insulin secretion, and their β cells revealed scarce emiocytotic images and a marked increase of intracellular granulolysis. These results represent the ultrastructural correlate of the reduced insulin secretion produced by metabolic alkalosis in the perfused rat pancreas. | |
| dc.description | Centro de Endocrinología Experimental y Aplicada | |
| dc.format | application/pdf | |
| dc.format | 159-163 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Biología | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Insulin secretion | |
| dc.subject | Electron microscopy | |
| dc.subject | Acid-base changes | |
| dc.subject | Pancreas perfusion | |
| dc.title | Ultrastructural responses of pancreatic β cells to metabolic alkalosis | |
| dc.type | Articulo | |
| dc.type | Articulo | |
