IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts

dc.creatorRojas, R. E.
dc.creatorDemichelis, Sandra O.
dc.creatorSarno, E. N.
dc.creatorSegal-Eiras, Amada
dc.date1997-09-01
dc.date2022-09-01T16:01:23Z
dc.date.accessioned2023-07-15T04:49:42Z
dc.date.available2023-07-15T04:49:42Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/141456
dc.identifierissn:0928-8244
dc.identifierissn:1574-695X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7471037
dc.descriptionThe aim of the present work was to evaluate the levels of anti-PGL-I and anti-10-kDa heat shock protein antibodies in serum and immune complexes isolated from leprosy patients, convivients and controls. Leprosy patients with erythema nodosum leprosum or without it were included and a comparative study was done to investigate intergroup differences. Immune complexes were precipitated from serum by polyethylene glycol 3.5%; antibody levels were measured in sera and in dissociated immune complexes by ELISA. Serum antibody levels were then correlated with immune complex-associated antibody levels. The results showed that the erythema nodosum leprosum group differed from controls, contacts and non-erythema patients in their immune complex levels. IgM anti-PGL-I and IgG anti-10-kDa heat shock protein antibodies were constituents of the immune complexes in patients with erythema nodosum leprosum, who exhibited a significant difference in their immune complex composition compared with controls, contacts and non-erythema patients; while free antibody levels (anti-PGL-I and anti-10-kDa) did not differentiate between erythema and non-erythema patients, the measurement of immune complex-associated antibodies demonstrated a significant difference between the two clinical conditions. Furthermore, the measurement of immune complex-associated anti-PGL-I IgM made it possible to differentiate between contacts and controls. The significance of these results is discussed.
dc.descriptionCentro de Investigaciones Inmunológicas Básicas y Aplicadas
dc.formatapplication/pdf
dc.format65-74
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectLeprosy
dc.subjectErythema nodosum leprosum
dc.subjectImmune complex
dc.subjectPhenolic glycolipid I
dc.subject10-kDa Heat shock protein
dc.titleIgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts
dc.typeArticulo
dc.typeArticulo


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