| dc.creator | Cingolani, Horacio Eugenio | |
| dc.creator | Pérez, Néstor Gustavo | |
| dc.creator | Camilión de Hurtado, María Cristina | |
| dc.date | 2003 | |
| dc.date | 2022-03-28T15:43:20Z | |
| dc.date.accessioned | 2023-07-15T04:38:42Z | |
| dc.date.available | 2023-07-15T04:38:42Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/133387 | |
| dc.identifier | issn:1389-1774 | |
| dc.identifier | isbn:978-1-4615-0347-7 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7470342 | |
| dc.description | An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves the release of angiotensin II (Ang II), the release/increased formation of endothelin (ET), the activation of the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), the increase in intracellular Na<sup>+</sup> concentration ([Na<sup>+</sup>]<sub>i</sub>), and the increase in the Ca<sup>2+</sup> transient that underlies the so called slow force response (SFR) to stretch. This autocrine/paracrine mechanism could explain how a change in afterload alters cardiac contractility as was reported by Anrep in 1912. | |
| dc.description | Facultad de Ciencias Médicas | |
| dc.format | application/pdf | |
| dc.format | 37-48 | |
| dc.language | es | |
| dc.publisher | Springer | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Medicina | |
| dc.subject | myocardial stretch | |
| dc.subject | Na+/Ca2+ exchange | |
| dc.subject | angiotensin II | |
| dc.subject | endothelin hypertrophy | |
| dc.title | Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart | |
| dc.type | Libro | |
| dc.type | Capitulo de libro | |
