| dc.creator | Machado, Ignacio Raúl | |
| dc.creator | Marino, Leonardo B. | |
| dc.creator | Demoro, Bruno | |
| dc.creator | Echeverría, Gustavo Alberto | |
| dc.creator | Piro, Oscar Enrique | |
| dc.creator | Fujimura Leite, Clarice Queico | |
| dc.creator | Pavan, Fernando Rogério | |
| dc.creator | Gambino, Dinorah | |
| dc.date | 2014-09-27 | |
| dc.date | 2021-11-16T17:52:57Z | |
| dc.date.accessioned | 2023-07-15T04:03:47Z | |
| dc.date.available | 2023-07-15T04:03:47Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/128228 | |
| dc.identifier | issn:1768-3254 | |
| dc.identifier | issn:0223-5234 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7468108 | |
| dc.description | In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [M(III)(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Attempts to crystallize [Ga(III)(mpo)3] in CH2Cl2 led to single crystals of the reaction product [GaCl(mpo)2], where the gallium(III) ion is in a square basis pyramidal environment, trans-coordinated at the basis to two pyridine-2-thiolato 1-oxide anions acting as bidentate ligands through their oxygen and sulfur atoms. The biological activity of the new [M(III)(mpo)3] complexes together with that of the previously reported Fe(III) analogous compound and the pyridine-2-thiol 1-oxide sodium salt (Na mpo) was evaluated on Mycobacterium tuberculosis. The compounds showed excellent activity, both in the standard strain H37Rv ATCC 27294 (pan-susceptible) and in five clinical isolates that are resistant to the standard first-line anti-tuberculosis drugs isoniazid and rifampicin. These pyridine-2-thiol 1-oxide derivatives are promising compounds for the treatment of resistant tuberculosis. | |
| dc.description | Instituto de Física La Plata | |
| dc.format | application/pdf | |
| dc.format | 267-273 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | |
| dc.subject | Química | |
| dc.subject | Gallium(III) | |
| dc.subject | Bismuth(III) | |
| dc.subject | Iron(III) | |
| dc.subject | Mycobacterium tuberculosis | |
| dc.subject | Pyridine-2-thiol 1-oxide compounds | |
| dc.title | Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents | |
| dc.type | Articulo | |
| dc.type | Articulo | |
