dc.creator | Cereijido, M. | |
dc.creator | Ponce, A. | |
dc.creator | Larre, M. I. | |
dc.creator | Castillo, A. | |
dc.creator | Hinojosa, L. | |
dc.date | 2015 | |
dc.date | 2021-11-04T17:49:07Z | |
dc.date.accessioned | 2023-07-15T04:00:06Z | |
dc.date.available | 2023-07-15T04:00:06Z | |
dc.identifier | http://sedici.unlp.edu.ar/handle/10915/127779 | |
dc.identifier | https://pmr.safisiol.org.ar/archive/id/78 | |
dc.identifier | issn:1669-5402 | |
dc.identifier | issn:1669-5410 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7467872 | |
dc.description | Ouabain, a substance obtained from plant extracts, has been long known as cardiotonic, as well as by its high affinity to the Na-K- ATPase pump. The recent finding that ouabain is endogenously expressed in mammals has prompted research to determine its role as a hormone. We have shown that, in a physiological level (10 nM), it influences on three important features of epithelial physiology related to cell to cell contacts: (1) It modifies the Tight Junction integrity, as reflected by an increase in the Transepithelial Electrical Resistance (TER) of mature monolayers of MDCK cells. (2) It speeds up ciliogenesis, a feature closely related to epithelial (Apical/Basolateral) polarity and (3) It triggers Gap Junctional Intercellular Communication (GJIC). Since lack of GJIC has been associated to cancer, ouabain may be an interesting player on this issue. | |
dc.description | Sociedad Argentina de Fisiología | |
dc.format | application/pdf | |
dc.format | 46-62 | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
dc.subject | Ciencias Médicas | |
dc.subject | ouabain | |
dc.subject | epithelia | |
dc.subject | tight junctions | |
dc.subject | gap junctions | |
dc.subject | connexins | |
dc.subject | cancer | |
dc.title | Physiological role of hormone ouabain | |
dc.type | Articulo | |
dc.type | Revision | |