Gene therapy for the treatment of pituitary tumors

dc.creatorRodríguez, Silvia Susana
dc.creatorCastro, María Graciela
dc.creatorBrown, Oscar Alfredo
dc.creatorGoya, Rodolfo Gustavo
dc.creatorCónsole-Avegliano, Gloria Miriam
dc.date2009-07-01
dc.date2021-10-22T15:31:55Z
dc.date.accessioned2023-07-15T03:49:45Z
dc.date.available2023-07-15T03:49:45Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/127128
dc.identifierissn:1744-6651
dc.identifierissn:1744-8417
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7467211
dc.descriptionPituitary adenomas constitute the most frequent neuroendocrine pathology in humans. Current therapies include surgery, radiotherapy and pharmacological approaches. Although useful, none of them offers a permanent cure. Current research efforts to implement gene therapy in pituitary tumors include the treatment of experimental adenomas with adenoviral vector-mediated transfer of the suicide gene for thymidine kinase, which converts the prodrug ganciclovir into a toxic metabolite. In some cases, the suicide transgene has been placed under the control of pituitary cell-type specific promoters. Also, regulatable adenoviral vector systems are being assessed in gene therapy approaches for experimental pituitary tumors. Although the efficiency and safety of current viral vectors must be optimized before clinical use, they remain as highly promising therapeutic tools.
dc.descriptionInstituto de Investigaciones Bioquímicas de La Plata
dc.descriptionComisión de Investigaciones Científicas de la provincia de Buenos Aires
dc.formatapplication/pdf
dc.format359-370
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectGene therapy
dc.subjectViral vectors
dc.subjectPituitary tumors
dc.subjectIGF-I gene therapy
dc.subjectNeurosurgery
dc.subjectSuicide gene therapy
dc.subjectProapoptotic genes
dc.subjectCombined therapy
dc.titleGene therapy for the treatment of pituitary tumors
dc.typeArticulo
dc.typePreprint


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