| dc.creator | Aguilera, Anabella | |
| dc.creator | Berdun, Federico | |
| dc.creator | Bartoli, Carlos Guillermo | |
| dc.creator | Steelheart Molina, María Charlotte | |
| dc.creator | Alegre, Matías Leonel | |
| dc.creator | Salerno, Graciela L. | |
| dc.creator | Pagnussat, Gabriela Carolina | |
| dc.creator | Martin, María Victori | |
| dc.date | 2019-11-02 | |
| dc.date | 2021-09-21T17:47:18Z | |
| dc.date.accessioned | 2023-07-15T03:16:37Z | |
| dc.date.available | 2023-07-15T03:16:37Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/125291 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7465099 | |
| dc.description | Ferroptosis is an oxidative iron-dependent form of cell death recently described in eukaryotic organisms like animals, plants and parasites. Here we report that a similar process takes place in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis cells undergo a cell death pathway that can be suppressed by canonical ferroptosis inhibitors or by external addition of calcium, glutathione or ascorbic acid. Moreover, as described for eukaryotic cells ferroptosis, this pathway is characterized by an early depletion of antioxidants, and by lipid peroxidation. As in general prokaryotes membranes contain poorly oxidizable saturated or monounsaturated lipid molecules, it was thought that they were not susceptible to ferroptosis. Interestingly, cyanobacteria contain thylakoid membranes that are enriched in polyunsaturated-fatty-acid-containing phospholipids, which might explain their sensitivity to ferroptosis. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program. | |
| dc.description | Instituto de Fisiología Vegetal | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Agrarias | |
| dc.subject | Ciencias Naturales | |
| dc.subject | ferroptosis | |
| dc.subject | photosynthetic prokaryote | |
| dc.subject | Synechocystis | |
| dc.title | Heat stress induces ferroptosis in a photosynthetic prokaryote | |
| dc.type | Articulo | |
| dc.type | Preprint | |
