Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance

dc.creatorFittipaldi, Antonela Soledad
dc.creatorHernández, Julieta M.
dc.creatorCastrogiovanni, Daniel Cayetano
dc.creatorLufrano, Daniela
dc.creatorDe Francesco, Pablo Nicolás
dc.creatorGarrido, Verónica
dc.creatorVitaux, Patrick
dc.creatorFasano, María Victoria
dc.creatorFehrentz, Jean Alain
dc.creatorFernández, Adriana
dc.creatorAndreoli, María F.
dc.creatorPerelló, Mario Carlos
dc.date2020
dc.date2021-09-06T15:48:04Z
dc.date.accessioned2023-07-15T03:12:45Z
dc.date.available2023-07-15T03:12:45Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/124194
dc.identifierissn:1479-683X
dc.identifierissn:0804-4643
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7464855
dc.descriptionObjective: The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin receptor that blocks the effects of ghrelin. Some evidences show that plasma levels of these peptides are altered in adults with obesity, but their levels in childhood obesity remain poorly studied. Therefore, the objective of this study was to assess fasting plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with normoweight, overweight/obesity and their association with different anthropometric and metabolic variables. Design: A total of 42 females and 40 males, ages 3–12 years old were enrolled as a cross-sectional cohort. Results: Plasma levels of des-acyl ghrelin and LEAP2 (but not ghrelin) were lower and ghrelin/des-acyl ghrelin ratio was higher in children with overweight/obesity. Des-acyl ghrelin negatively correlated with age, BMI z-score, insulin and HOMA index, and the correlations were stronger in children with overweight/obesity. LEAP2 levels negatively correlated with BMI z-score. No gender differences were found. Conclusions: Our findings suggest that ghrelin tone is increased in childhood obesity, due to a decrease on plasma levels of des-acyl ghrelin and LEAP2, and that des-acyl ghrelin is associated to insulin resistance, particularly in children with overweight/obesity.
dc.descriptionFacultad de Ciencias Médicas
dc.descriptionInstituto Multidisciplinario de Biología Celular
dc.descriptionFacultad de Ciencias Exactas
dc.formatapplication/pdf
dc.format165-175
dc.languagees
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectMedicina
dc.subjectCiencias Exactas
dc.subjectplasma levels
dc.subjectghrelin
dc.subjectchildhood obesity
dc.subjectinsulin resistance
dc.titlePlasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance
dc.typeArticulo
dc.typeArticulo


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