Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor

dc.creatorAccialini, Paula
dc.creatorAbán, Cyntia
dc.creatorEtcheverry, Tomás
dc.creatorNegri Malbrán, Mercedes
dc.creatorLeguizamón, Gustavo
dc.creatorHerlax, Vanesa Silvana
dc.creatorMaté, Sabina María
dc.creatorFarina, Mariana
dc.date2021-05
dc.date2021-09-13T15:18:29Z
dc.date.accessioned2023-07-15T03:08:41Z
dc.date.available2023-07-15T03:08:41Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/124686
dc.identifierissn:1664-042X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7464606
dc.descriptionThe onset of labor involves the action of multiple factors and recent reports have postulated the endocannabinoid system as a new regulator of this process. Our objective was to study the role of anandamide, one of the main endocannabinoids, on the regulation of placental molecules that contribute to the onset of labor at term. Placental samples were obtained from patients with laboring vaginal deliveries and from non-laboring elective cesarean sections. Vaginal delivery placentas produced higher prostaglandins levels than cesarean section samples. Besides, no differences were observed in NOS basal activity between groups. Incubation of vaginal delivery placentas with anandamide increased prostaglandins concentration and decreased NOS activity. Antagonism of type-1cannabinoid receptor (CB1) did not alter the effect observed on NOS activity. Conversely, incubation of cesarean section placentas with anandamide reduced prostaglandins levels and enhanced NOS activity, the latter involving the participation of CB1. Furthermore, we observed a differential expression of the main components of the endocannabinoid system between placental samples, being the change in CB1 localization the most relevant finding. Our results suggest that anandamide acts as a modulator of the signals that regulate labor, exerting differential actions depending on CB1 localization in laboring or non-laboring term placentas.
dc.descriptionFacultad de Ciencias Médicas
dc.descriptionInstituto de Investigaciones Bioquímicas de La Plata
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.subjectMedicina
dc.subjectBioquímica
dc.subjectanandamide
dc.subjectprostaglandins
dc.subjectnitric oxide synthase
dc.subjectPlacenta
dc.subjectlabor
dc.titleAnandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
dc.typeArticulo
dc.typeArticulo


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