dc.creatorMeneses, María Laura
dc.creatorAlbarellos, G. A.
dc.creatorLandoni, María Fabiana
dc.date2012
dc.date2021-09-03T18:43:21Z
dc.date.accessioned2023-07-15T02:56:09Z
dc.date.available2023-07-15T02:56:09Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/124137
dc.identifierissn:2038-9698
dc.identifierissn:2038-9701
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7463827
dc.descriptionThe increase in bacterial resistance to antimicrobials has motivated researchers to develop experimental animal models to integrate pharmacokinetic/pharmacodynamic (PK/ PD) profiles to predict the effectiveness of antimicrobials treatments. The models used to date have a weakness based on the use of the minimum inhibitory concentration (MIC), whose value is obtained only in vitro , determined under constant conditions with an exponential error, regarding to the double dilution used. The aim of this study was to develop and validate a device for subcutaneous implantation, which can be applied in any animal species, allowing simultaneous description of in vivo bacterial killing curve and pharmacokinetic profile of the drug under study. Based on the obtained results, it can be concluded that the use of this model will allow researchers to apply PK/ PD decreasing the error originated in the use of MIC as a measure of antimicrobial pharmacodynamics.
dc.descriptionFacultad de Ciencias Veterinarias
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)
dc.subjectCiencias Veterinarias
dc.subjectPharmacokinetic
dc.subjectPharmacodynamic
dc.subjectMinimum inhibitory concentration
dc.subjectAntimicrobials
dc.titleDevelopment and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals
dc.typeArticulo
dc.typeArticulo


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