Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

dc.creatorGarcés, María Fernanda
dc.creatorBuell-Acosta, Julieth Daniela
dc.creatorRodriguez-Navarro, Haiver Antonio
dc.creatorPulido-Sánchez, Estefania
dc.creatorRincon-Ramírez, Juan José
dc.creatorMoreno-Ordóñez, Diana Carolina
dc.creatorFranco-Vega, Roberto
dc.creatorRoncancio-Muñoz, Jhoan Sebastian
dc.creatorBurgos-Cardenas, Alvaro Javier
dc.creatorLacunza, Ezequiel
dc.creatorCastaño, Justo P.
dc.creatorDieguez, Carlos
dc.creatorNogueiras, Rubén
dc.creatorSanchez, Elizabeth
dc.creatorCaminos, Jorge E.
dc.date2020-12-03
dc.date2021-08-26T13:15:08Z
dc.date.accessioned2023-07-15T02:53:16Z
dc.date.available2023-07-15T02:53:16Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/123483
dc.identifierissn:2045-2322
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7463647
dc.descriptionThis study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m<sup>2</sup>) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m<sup>2</sup>) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
dc.descriptionCentro de Investigaciones Inmunológicas Básicas y Aplicadas
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectANGPTL3 serum levels
dc.subjectGlucose tolerance
dc.titleSerum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
dc.typeArticulo
dc.typeArticulo


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