Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate

dc.creatorBrenner, Rodolfo Roberto
dc.creatorNervi, Aníbal Mario
dc.date1965
dc.date2021-08-26T15:20:59Z
dc.date.accessioned2023-07-15T02:43:47Z
dc.date.available2023-07-15T02:43:47Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/123518
dc.identifierissn:0022-2275
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7463055
dc.descriptionChanges induced by dietary methyl linoleate and arachidonate in the fatty acid composition of liver phosphatidyl choline, phosphatidyl ethanolamine, cholesterol esters, and triglycerides were investigated in essential fatty aciddeficient rats. The esters were fed for 0, 24, 50, 96, 192, and 360 hr. The lipids were fractionated by thin-layer chromatography and the fatty acid composition was estimated by gas liquid chromatography. Acids bound to the a'- and 8-carbons of phosphatides were separated by lipolysis with phospholipase A. From the compositions found it was deduced that both dietary linoleate and arachidonate inhibited eicosatrienoate synthesis from oleate but that only arachidonate replaced eicosatrienoate quantitatively in the 8-position of lecithin and cephalin. Both dietary acids displaced some of the &positioned oleate. Monoenoic: saturated acid ratios were also decreased by both esters both in triglycerides and in a'-bound acids in phosphatides. In triglycerides this change preceded any significant incorporation of linoleate or arachidonate. Arachidonate effects seemed to be more rapid and more marked than those of linoleate and although final compositions were similar, because of the conversion of linoleate into arachidonate, a different pattern of reactions led to these results.
dc.descriptionFacultad de Ciencias Médicas
dc.formatapplication/pdf
dc.format363-368
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectkinetics
dc.subjectlinoleic
dc.subjectarachidonic
dc.subjectincorporation
dc.subjecteicosatrienoic depletion
dc.subjectliver lipids
dc.subjectrat
dc.subjectcholine
dc.subjectglycerophosphatides
dc.subjectethanolamine
dc.subjectglycerophosphatides
dc.subjectphospholipase A
dc.subjecttriglycerides
dc.titleKinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
dc.typeArticulo
dc.typeArticulo


Este ítem pertenece a la siguiente institución