Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study

dc.creatorLarramendy, Marcelo Luis
dc.creatorMajander, Päivi
dc.creatorSaarto, Tiina
dc.creatorTenhunen, Mikko
dc.creatorCaballín, Rosa
dc.creatorElomaa, Inkeri
dc.creatorKnuutila, Sakari
dc.date1998
dc.date2021-08-18T14:04:36Z
dc.date.accessioned2023-07-15T02:42:00Z
dc.date.available2023-07-15T02:42:00Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/122867
dc.identifierissn:0165-4608
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7462943
dc.descriptionThe frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.
dc.descriptionFacultad de Ciencias Naturales y Museo
dc.formatapplication/pdf
dc.format57-62
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBiología
dc.subjectCiencias Médicas
dc.subjectChromosomal translocation
dc.subjectMolecular biology
dc.subjectCytogenetics
dc.subjectFluorescence in situ hybridization
dc.subjectIn situ
dc.subjectBreast Adenocarcinoma
dc.subjectRadiation therapy
dc.subjectBreast cancer
dc.subjectMetaphase
dc.subjectBiology
dc.subjectAged
dc.subjectBreast Neoplasms/genetics
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.titleRadiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
dc.typeArticulo
dc.typeArticulo


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