dc.creatorRodenak Kladniew, Boris Emilio
dc.creatorCastro, María Agustina
dc.creatorCrespo, Rosana
dc.creatorGalle, Marianela
dc.creatorGarcía de Bravo, Margarita María
dc.date2020-12
dc.date2021-05-31T16:12:32Z
dc.date.accessioned2023-07-15T01:53:02Z
dc.date.available2023-07-15T01:53:02Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/119509
dc.identifierissn:2405-8440
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7459961
dc.descriptionLinalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was to determine the anticancer mechanisms of action of linalool and 1,8-cineole in lung adenocarcinoma A549 cells. Linalool (0–2.0 mM) and 1,8-cineole (0–8.0 mM) inhibited cell proliferation by inducing G0/G1 and/or G2/M cell cycle arrest without affecting cell viability of normal lung WI-38 cells. None of the two monoterpenes were able to induce apoptosis, as observed by the lack of caspase-3 and caspase-9 activation, PARP cleavage, and DNA fragmentation. Linalool, but not 1,8-cineole, increased reactive oxygen species production and mitochondrial membrane potential depolarization. Reactive oxygen species were involved in cell growth inhibition and mitochondrial depolarization induced by linalool since the antioxidant N-acetyl-L-cysteine prevented both effects. Besides, linalool (2.0 mM) and 1,8-cineole (8.0 mM) inhibited A549 cell migration. The combination of each monoterpene with simvastatin increased the G0/G1 cell cycle arrest and sensitized cells to apoptosis compared with simvastatin alone. Our results showed that both monoterpenes might be promising anticancer agents with antiproliferative, anti-metastatic, and sensitizer properties for lung cancer therapy.
dc.descriptionInstituto de Investigaciones Bioquímicas de La Plata
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.subjectCiencias Médicas
dc.subjectLinalool
dc.subject1,8-Cineole
dc.subjectNon-small lung cancer cells
dc.subjectCytostatic effects
dc.subjectReactive oxygen species
dc.subjectCell migration
dc.subjectChemosensitizers
dc.subjectCell biology
dc.subjectCell culture
dc.subjectCytotoxicity
dc.subjectBioactive plant product
dc.subjectPharmaceutical science
dc.subjectNatural product
dc.subjectBiochemistry
dc.subjectOxidative stress
dc.subjectCancer research
dc.subjectChemotherapy
dc.titleAnti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
dc.typeArticulo
dc.typeArticulo


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