| dc.creator | Mosca, Susana María | |
| dc.creator | Schinella, Guillermo Raúl | |
| dc.creator | Tournier, Horacio Alfio | |
| dc.creator | Cingolani, Horacio Eugenio | |
| dc.date | 2001 | |
| dc.date | 2020-10-26T16:12:45Z | |
| dc.date.accessioned | 2023-07-14T22:47:00Z | |
| dc.date.available | 2023-07-14T22:47:00Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/107697 | |
| dc.identifier | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2858997&blobtype=pdf | |
| dc.identifier | issn:1918-1515 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7448189 | |
| dc.description | Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury.
Animals and methods: The antioxidant properties of three RWE were determined using different free radicalgenerating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 µg/mL of RWE 1 (cabernetsauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function.
Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4%, 47±9% and 43±14% for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picrylhydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4% and 62±5%, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4% and 101±4% for RWE 1 and 92±5% and 91±5% for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction.
Conclusion: These data show that although the three nonalcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts. | |
| dc.description | Centro de Investigaciones Cardiovasculares | |
| dc.format | application/pdf | |
| dc.format | 183-187 | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Antioxidant capacity | |
| dc.subject | Ischemia | |
| dc.subject | Red wine | |
| dc.subject | Reperfusion | |
| dc.title | Is the protection against ischemia induced by red wine linked to its antioxidant capacity? | |
| dc.type | Articulo | |
| dc.type | Articulo | |
