dc.creatorCaminero, Alberto
dc.creatorMcCarville, Justin L.
dc.creatorGalipeau, Heather J.
dc.creatorDeraison, Celine
dc.creatorBernier, Steve P.
dc.creatorConstante, Marco
dc.creatorRolland, Corinne
dc.creatorMeisel, Marlies
dc.creatorMurray, Joseph A.
dc.creatorYu, Xuechen B.
dc.creatorAlaedini, Armin
dc.creatorCoombes, Brian K.
dc.creatorBercik, Premysl
dc.creatorSouthward, Carolyn M.
dc.creatorRuf, Wolfram
dc.creatorJabri, Bana
dc.creatorChirdo, Fernando Gabriel
dc.creatorCasqueiro, Javier
dc.creatorSurette, Michael G.
dc.creatorVergnolle, Nathalie
dc.creatorVerdu, Elena F.
dc.date2019
dc.date2020-10-15T14:46:10Z
dc.date.accessioned2023-07-14T22:46:13Z
dc.date.available2023-07-14T22:46:13Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/107005
dc.identifierhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6416356&blobtype=pdf
dc.identifierissn:2041-1723
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7448138
dc.descriptionMicrobe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity characterized by a breakdown of oral tolerance to gluten proteins in genetically predisposed individuals, although the underlying mechanisms are incompletely understood. Here we show that duodenal biopsies from patients with active CeD have increased proteolytic activity against gluten substrates that correlates with increased Proteobacteria abundance, including Pseudomonas. Using Pseudomonas aeruginosa producing elastase as a model, we show gluten-independent, PAR-2 mediated upregulation of inflammatory pathways in C57BL/6 mice without villus blunting. In mice expressing CeD risk genes, P. aeruginosa elastase synergizes with gluten to induce more severe inflammation that is associated with moderate villus blunting. These results demonstrate that proteases expressed by opportunistic pathogens impact host immune responses that are relevant to the development of food sensitivities, independently of the trigger antigen.
dc.descriptionInstituto de Estudios Inmunológicos y Fisiopatológicos
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBiología
dc.subjectProteases
dc.subjectMicrobe-host interactions
dc.subjectFood sensitivities
dc.titleDuodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
dc.typeArticulo
dc.typeArticulo


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