Influence of individual cell motility on the 2D front roughness dynamics of tumour cell colonies

dc.creatorMuzzio, Nicolás Eduardo
dc.creatorPasquale, Miguel Ángel
dc.creatorGonzález, Pedro Horacio
dc.creatorArvia, Alejandro Jorge
dc.date2014
dc.date2020-10-27T11:29:22Z
dc.date.accessioned2023-07-14T22:46:06Z
dc.date.available2023-07-14T22:46:06Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/107740
dc.identifierhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4059834&blobtype=pdf
dc.identifierissn:1573-0689
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7448131
dc.descriptionThe dynamics of in situ 2D HeLa cell quasi-linear and quasi-radial colony fronts in a standard culture medium is investigated. For quasi-radial colonies, as the cell population increased, a kinetic transition from an exponential to a constant front average velocity regime was observed. Special attention was paid to individual cell motility evolution under constant average colony front velocity looking for its impact on the dynamics of the 2D colony front roughness. From the directionalities and velocity components of cell trajectories in colonies with different cell populations, the influence of both local cell density and cell crowding effects on individual cell motility was determined. The average dynamic behaviour of individual cells in the colony and its dependence on both local spatio-temporal heterogeneities and growth geometry suggested that cell motion undergoes under a concerted cell migration mechanism, in which both a limiting random walk-like and a limiting ballistic-like contribution were involved. These results were interesting to infer how biased cell trajectories influenced both the 2D colony spreading dynamics and the front roughness characteristics by local biased contributions to individual cell motion. These data are consistent with previous experimental and theoretical cell colony spreading data and provide additional evidence of the validity of the Kardar-Parisi-Zhang equation, within a certain range of time and colony front size, for describing the dynamics of 2D colony front roughness.
dc.descriptionInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
dc.formatapplication/pdf
dc.format285–308
dc.languagees
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectCiencias Exactas
dc.subjectCell population
dc.subjectColony spatio-temporal heterogeneity
dc.subjectCrowding effects
dc.subjectBiased cell trajectories
dc.subjectCell migration concerted mechanism
dc.titleInfluence of individual cell motility on the 2D front roughness dynamics of tumour cell colonies
dc.typeArticulo
dc.typeArticulo


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