Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction

dc.creatorMartín, Pedro
dc.creatorRebolledo, Alejandro
dc.creatorRoldán Palomo, Ana Rocío
dc.creatorMoncada, Melisa
dc.creatorPiccinini, Luciano
dc.creatorMilesi, Verónica
dc.date2014
dc.date2020-10-23T18:31:23Z
dc.date.accessioned2023-07-14T22:46:01Z
dc.date.available2023-07-14T22:46:01Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/107645
dc.identifierhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3960844&blobtype=pdf
dc.identifierissn:1933-7205
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7448127
dc.descriptionThrough their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
dc.descriptionGrupo de Investigación en Fisiología Vascular
dc.formatapplication/pdf
dc.format432-441
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBiología
dc.subjectHuman umbilical artery
dc.subjectK+ channels
dc.subjectPatch-clamp
dc.titleDiversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
dc.typeArticulo
dc.typeRevision


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