Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
Tratamento prévio com adalimumabe reduz lesão pulmonar induzida por ventilação mecânica em um modelo experimental
| dc.creator | Correger, Enrique | |
| dc.creator | Marcos, Josefina | |
| dc.creator | Laguens, Graciela | |
| dc.creator | Stringa, Pablo Luis | |
| dc.creator | Cardinal Fernández, Pablo | |
| dc.creator | Blanch, Lluis | |
| dc.date | 2020 | |
| dc.date | 2020-10-27T13:47:55Z | |
| dc.date.accessioned | 2023-07-14T22:43:19Z | |
| dc.date.available | 2023-07-14T22:43:19Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/107778 | |
| dc.identifier | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf | |
| dc.identifier | issn:0103-507X | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7447958 | |
| dc.description | Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI). Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volume group (n = 6), where tidal volume = 8mL/kg and positive end-expiratory pressure = 5cmH2O; a high tidal volume group (n = 6), where tidal volume = 35mL/kg and positive end-expiratory pressure = 0; and a pretreated + high tidal volume group (n = 6) where adalimumab (100ug/kg) was administered intraperitoneally 24 hours before mechanical ventilation + tidal volume = 35mL/ kg and positive end-expiratory pressure = 0. ANOVA was used to compare histological damage (ATS 2010 Lung Injury Scoring System), pulmonary edema, lung compliance, arterial partial pressure of oxygen, and mean arterial pressure among the groups. Results: After 3 hours of ventilation, the mean histological lung injury score was higher in the high tidal volume group than in the low tidal volume group (0.030 versus 0.0051, respectively, p = 0.003). The high tidal volume group showed diminished lung compliance at 3 hours (p = 0.04) and hypoxemia (p = 0,018 versus control). Pretreated HVt group had an improved histological score, mainly due to a significant reduction in leukocyte infiltration (p = 0.003). Conclusion: Histological examination after 3 hours of injurious ventilation revealed ventilator-induced lung injury in the absence of measurable changes in lung mechanics or oxygenation; administering adalimumab before mechanical ventilation reduced lung edema and histological damage. | |
| dc.description | Facultad de Ciencias Médicas | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Médicas | |
| dc.subject | Adalimumab/administration & dosage | |
| dc.subject | Respiration, artificial | |
| dc.subject | Respiratory failure | |
| dc.subject | Ventilator-induced lung injury | |
| dc.title | Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model | |
| dc.title | Tratamento prévio com adalimumabe reduz lesão pulmonar induzida por ventilação mecânica em um modelo experimental | |
| dc.type | Articulo | |
| dc.type | Articulo |