Current State and Future Perspectives in QSAR Models to Predict Blood Brain Barrier penetration in Central Nervous System Drug R&D

dc.creatorMorales, Juan Francisco
dc.creatorScioli Montoto, Sebastián
dc.creatorFagiolino, Pietro
dc.creatorRuiz, María
dc.date2017
dc.date2020-09-02T18:33:30Z
dc.date.accessioned2023-07-14T21:50:33Z
dc.date.available2023-07-14T21:50:33Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/103692
dc.identifierissn:1389-5575
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7444616
dc.descriptionThe blood brain barrier (BBB) is a physical and biochemical barrier that restricts the entry of certain drugs to the Central Nervous System (CNS), while allowing the passage of others. The ability to predict the permeability of a given molecule through the BBB is a key aspect in CNS drug discovery and development, since neurotherapeutic agents with molecular targets in the CNS should be able to cross the BBB, whereas peripherally acting agents should not, to minimize the risk of CNS adverse effects. In this review we examine and discuss QSAR approaches and current availability of experimental data for the construction of BBB permeability predictive models, focusing on the modeling of the biorelevant parameter unbound partitioning coefficient (Kp,uu) . Emphasis is made on two possible strategies to overcome the current limitations of in silico models: considering the prediction of brain penetration as a multifactorial problem, and increasing experimental datasets through accurate and standardized experimental techniques.
dc.descriptionFacultad de Ciencias Exactas
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBiología
dc.subjectBlood-brain barrier
dc.subjectBrain penetration
dc.subjectCentral nervous system
dc.subjectMicrodialysis
dc.subjectPassive difussion
dc.subjectPharmacokinetic
dc.subjectQSAR models
dc.subjectProtein binding,
dc.subjectUnbound drug fraction
dc.titleCurrent State and Future Perspectives in QSAR Models to Predict Blood Brain Barrier penetration in Central Nervous System Drug R&D
dc.typeArticulo
dc.typeArticulo


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