Computer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy

dc.creatorCouyoupetrou, Manuel
dc.creatorGantner, Melisa Edith
dc.creatorDi Ianni, Mauricio Emiliano
dc.creatorPalestro, Pablo Hernán
dc.creatorEnrique, Andrea Verónica
dc.creatorGavernet, Luciana
dc.creatorRuiz, María Esperanza
dc.creatorPesce, Guido
dc.creatorBruno Blanch, Luis Enrique
dc.creatorTalevi, Alan
dc.date2017
dc.date2020-08-31T12:59:16Z
dc.date.accessioned2023-07-14T21:46:40Z
dc.date.available2023-07-14T21:46:40Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/103425
dc.identifierissn:1875-5607
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7444366
dc.descriptionDespite the introduction of more than 15 third generation antiepileptic drugs to the market from 1990 to the moment, about one third of the epileptic patients still suffer from refractory to intractable epilepsy. Several hypotheses seek to explain the failure of drug treatments to control epilepsy symptoms in such patients. The most studied one proposes that drug resistance might be related with regional overactivity of efflux transporters from the ATP-Binding Cassette (ABC) superfamily at the blood-brain barrier and/or the epileptic foci in the brain. Different strategies have been conceived to address the transporter hypothesis, among them inhibiting or down-regulating the efflux transporters or bypassing them through a diversity of artifices. Here, we review scientific evidence supporting the transporter hypothesis along with its limitations, as well as computer-assisted early recognition of ABC transporter substrates as an interesting strategy to develop novel antiepileptic drugs capable of treating refractory epilepsy linked to ABC transporters overactivity.
dc.descriptionLaboratorio de Investigación y Desarrollo de Bioactivos
dc.formatapplication/pdf
dc.format205-215
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectFarmacia
dc.subjectQuímica
dc.subjectABC transporters
dc.subjectABCB1
dc.subjectABCG2
dc.subjectAntiepileptic drugs
dc.subjectBreast cancer resistance protein
dc.subjectDrug discovery
dc.subjectP-glycoprotein
dc.subjectRefractory epilepsy
dc.subjectTransporter hypothesis
dc.titleComputer-Aided Recognition of ABC Transporters Substrates and Its Application to the Development of New Drugs for Refractory Epilepsy
dc.typeArticulo
dc.typeArticulo


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