Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment

dc.creatorCacicedo, Maximiliano Luis
dc.creatorIslan, Germán Abel
dc.creatorLeón, Ignacio Esteban
dc.creatorAlvarez, Vera Alejandra
dc.creatorChourpa, Igor
dc.creatorAllard Vannier, E.
dc.creatorGarcía Aranda, N.
dc.creatorDíaz Riascos, Z. V.
dc.creatorFernández, Y.
dc.creatorSchwartz, S.
dc.creatorAbasolo, Ibane
dc.creatorCastro, Guillermo Raúl
dc.date2018-10
dc.date2020-05-19T12:56:59Z
dc.date.accessioned2023-07-14T20:12:13Z
dc.date.available2023-07-14T20:12:13Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/96219
dc.identifierhttps://ri.conicet.gov.ar/11336/91815
dc.identifierissn:0927-7765
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7438306
dc.descriptionThe use of hybrid materials, where a matrix sustains nanoparticles controlling the release of the chemotherapeutic drug, could be beneficial for the treatment of primary tumors prior or after surgery. This localized chemotherapy would guarantee high drug concentrations at the tumor site while precluding systemic drug exposure minimizing undesirable side effects. We combined bacterial cellulose hydrogel (BC) and nanostructured lipid carriers (NLCs) including doxorubicin (Dox) as a drug model. NLCs loaded with cationic Dox (NLCs-H) or neutral Dox (NLCs-N) were fully characterized and their cell internalization and cytotoxic efficacy were evaluated in vitro against MDA-MB-231 cells. Thereafter, a fixed combination of NLCs-H and NLCs-N loaded into BC (BC-NLCs-NH) was assayed in vivo into an orthotopic breast cancer mouse model. NLCs-H showed low encapsulation efficiency (48%) and fast release of the drug while NLCs-N showed higher encapsulation (97%) and sustained drug release. Both NLCs internalized via endocytic pathway, while allowing a sustained release of the Dox, which in turn rendered IC50 values below of those of free Dox. Taking advantage of the differential drug release, a mixture of NLCs-N and NLCs-H was encapsulated into BC matrix (BC-NLCs-NH) and assayed in vivo, showing a significant reduction of tumor growth, metastasis incidence and local drug toxicities.
dc.descriptionCentro de Investigación y Desarrollo en Fermentaciones Industriales
dc.descriptionCentro de Química Inorgánica
dc.formatapplication/pdf
dc.format596-608
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectQuímica
dc.subjectBacterial cellulose
dc.subjectDrug delivery
dc.subjectBacterial cellulose
dc.subjectDoxorubicin
dc.subjectBreast cancer
dc.subjectHydrogel
dc.subjectLocalized chemotherapy
dc.subjectNanocomposite
dc.subjectNanostructured lipid carriers
dc.subjectNeo-adjuvant therapy
dc.subjectControlled release
dc.titleBacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment
dc.typeArticulo
dc.typeArticulo


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