Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015

dc.creatorTabesh, Maryam
dc.creatorMagliano, D.J.
dc.creatorTanamas, S.K.
dc.creatorSurmont, F.
dc.creatorBahendeka, S.
dc.creatorChiang, C. E.
dc.creatorElgart, Jorge Federico
dc.creatorGagliardino, Juan José
dc.creatorKalra, Sanjay
dc.creatorKrishnamoorthy, S.
dc.creatorLuk, Andrea
dc.creatorMaegawa, H.
dc.creatorMotala, A.A.
dc.creatorPirie, F.
dc.creatorRamachandran, A.
dc.creatorTayeb, K.
dc.creatorVikulova, O.
dc.creatorWong, J.
dc.creatorShaw, J.E.
dc.date2018
dc.date2020-05-26T14:19:44Z
dc.date.accessioned2023-07-14T19:58:44Z
dc.date.available2023-07-14T19:58:44Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/96677
dc.identifierhttps://ri.conicet.gov.ar/11336/94950
dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1111/dme.13858
dc.identifierissn:0742-3071
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7437431
dc.description<i>Aim</i>: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. <i>Methods</i>: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people. Each site summarized individual-level data from outpatient medical records for 2006 and 2015. <i>Data included</i>: demographic information, blood pressure (BP), total cholesterol levels and percentage of people taking statins, anti-hypertensive medication (angiotensin-converting enzyme inhibitors, calcium channel blockers, angiotensin II receptor blockers, thiazide diuretics) and antiplatelet drugs. <i>Results</i>: From 2006 to 2015, mean cholesterol levels decreased in six of eight sites (range: −0.5 to −0.2), whereas the proportion with BP levels > 140/90 mmHg increased in seven of eight sites. Decreases in cholesterol paralleled increases in statin use (range: 3.1 to 47.0 percentage points). Overall, utilization of anti-hypertensive medication did not change. However, there was an increase in the use of angiotensin II receptor blockers and a decrease in angiotensin-converting enzyme inhibitors. The percentage of individuals receiving calcium channel blockers and aspirin remained unchanged. <i>Conclusions</i>: Our findings indicate that control of cholesterol levels improved and coincided with increased use of statins. The percentage of people with BP > 140/90 mmHg was higher in 2015 than in 2006. Hypertension treatment shifted from using angiotensin-converting enzyme inhibitors to angiotensin II receptor blockers. Despite the potentially greater tolerability of angiotensin II receptor blockers, there was no associated improvement in BP levels.
dc.descriptionCentro de Endocrinología Experimental y Aplicada
dc.formatapplication/pdf
dc.format878-887
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightsCreative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.subjectSalud
dc.subjectMedicina
dc.subjectCiencias Médicas
dc.subjectEnfermedad cardiovascular
dc.subjectComplicaciones de la Diabetes
dc.subjectNorth america
dc.subjectWestern europe
dc.subjectEndocrinología
dc.titleCardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015
dc.typeArticulo
dc.typeArticulo


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