Heat stress induces ferroptosis-like cell death in plants

dc.creatorDistéfano, Ayelén Mariana
dc.creatorMartin, María Victoria
dc.creatorCórdoba, Juan Pablo
dc.creatorBellido, Andrés Martín
dc.creatorD’Ippólito, Sebastián
dc.creatorColman, Silvana Lorena
dc.creatorSoto, Débora
dc.creatorRoldán, Juan Alfredo
dc.creatorBartoli, Carlos Guillermo
dc.creatorZabaleta, Eduardo Julián
dc.creatorFiol, Diego Fernando
dc.creatorStockwell, Brent R.
dc.creatorDixon, Scott J.
dc.creatorPagnussat, Gabriela Carolina
dc.date2017
dc.date2019-12-13T17:37:22Z
dc.date.accessioned2023-07-14T17:45:29Z
dc.date.available2023-07-14T17:45:29Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/87410
dc.identifierissn:0021-9525
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7428723
dc.descriptionIn plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)-induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.
dc.descriptionInstituto de Fisiología Vegetal
dc.formatapplication/pdf
dc.format463-476
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectBiología
dc.subjectBotánica
dc.subjectCell death process
dc.subjectPlants
dc.subjectIron-dependent cell
dc.titleHeat stress induces ferroptosis-like cell death in plants
dc.typeArticulo
dc.typeArticulo


Este ítem pertenece a la siguiente institución