Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

dc.creatorBottasso Arias, Natalia María
dc.creatorGarcía, Marina
dc.creatorBondar, Constanza María
dc.creatorGuzman, Luciana
dc.creatorRedondo, Agustina
dc.creatorChopita, Néstor Alfredo
dc.creatorCórsico, Betina
dc.creatorChirdo, Fernando Gabriel
dc.date2015
dc.date2019-11-21T16:02:52Z
dc.date.accessioned2023-07-14T17:32:59Z
dc.date.available2023-07-14T17:32:59Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/85887
dc.identifierissn:0962-9351
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7427910
dc.descriptionCeliac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγ and inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs' expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.
dc.descriptionInstituto de Investigaciones Bioquímicas de La Plata
dc.descriptionInstituto de Estudios Inmunológicos y Fisiopatológicos
dc.formatapplication/pdf
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by/3.0/
dc.rightsCreative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.subjectCiencias Médicas
dc.subjectFatty Acid-Binding Proteins
dc.subjectCarrier Proteins
dc.subjectLiver fatty
dc.titleExpression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy
dc.typeArticulo
dc.typeArticulo


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