| dc.creator | Rodrigo Albors, Aida | |
| dc.creator | Tazaki, Akira | |
| dc.creator | Rost, Fabian | |
| dc.creator | Nowoshilow, Sergej | |
| dc.creator | Chara, Osvaldo | |
| dc.creator | Tanaka, Ely M. | |
| dc.date | 2015 | |
| dc.date | 2019-11-29T17:25:43Z | |
| dc.date.accessioned | 2023-07-14T17:30:07Z | |
| dc.date.available | 2023-07-14T17:30:07Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/86399 | |
| dc.identifier | issn:2050-084X | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7427722 | |
| dc.description | Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional program similar to embryonic neuroepithelial cells. This dedifferentiation includes the acquisition of rapid cell cycles, the switch from neurogenic to proliferative divisions, and the re-expression of planar cell polarity (PCP) pathway components. We show that PCP induction is essential to reorient mitotic spindles along the anterior-posterior axis of elongation, and orthogonal to the cell apical-basal axis. Disruption of this property results in premature neurogenesis and halts regeneration. Our findings reveal a key role for PCP in coordinating the morphogenesis of spinal cord outgrowth with the switch from a homeostatic to a regenerative stem cell that restores missing tissue. | |
| dc.description | Facultad de Ciencias Exactas | |
| dc.description | Instituto de Física de Líquidos y Sistemas Biológicos | |
| dc.format | application/pdf | |
| dc.language | en | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Creative Commons Attribution 4.0 International (CC BY 4.0) | |
| dc.subject | Ciencias Exactas | |
| dc.subject | Regeneration | |
| dc.subject | Spinal cord | |
| dc.title | Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration | |
| dc.type | Articulo | |
| dc.type | Articulo | |
