| dc.creator | Osorio, Héctor | |
| dc.creator | Finol, Héctor | |
| dc.creator | Gonzáles, Roschman | |
| dc.creator | Sardiñas, Carlos | |
| dc.date | 2022-11-26T23:30:11Z | |
| dc.date | 2022-11-26T23:30:11Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2023-07-13T15:10:52Z | |
| dc.date.available | 2023-07-13T15:10:52Z | |
| dc.identifier | Hector L. Osorio, Hector J. Finol, L. Roschman Gonzalez & Carlos E. Sardiñas (2018) Ultrastructure of colorectal adenocarcinoma and peritumoral tissue in untreated patients, Ultrastructural Pathology, 42:2, 81-90, DOI: 10.1080/01913123.2017.1422064 | |
| dc.identifier | 0191-3123 | |
| dc.identifier | 1521-0758 | |
| dc.identifier | http://hdl.handle.net/10872/21930 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/7422496 | |
| dc.description | In this study, we describe, compare, and discuss several subcellular alterations found in Colorectal
Adenocarcinoma and peritumoral tissue using transmission electron microscopy, morphometry,
and statistical analysis. Tissue samples from anterior resections were collected from patients
diagnosed with Colorectal Adenocarcinoma in the University Hospital of Caracas. Samples were
processed according to the typical protocol for their observation through transmission electron
microscopy. The resulting images were analyzed using specialized software for the collection of
morphometric data. Several anomalies were common for both tissues, including but not limited
to, rough endoplasmic reticulum and mitochondrial swelling, nuclear invagination, nuclear enlargement,
and cellular swelling. In general, alterations within the tumor were more frequent and
intense. Extensive organellar degradation and other evidences of cellular damage seemed to
extend past the edge of the tumor into the peritumoral tissue. There seems to be a clear process
of lateral cancerization present in the peritumoral area. The tissue layers composed of smooth
muscle cells, probably due to their structural features, may allow greater diffusion of harmful
substances produced by the tumor. A more in-depth analysis of peritumoral tissue considering
organellar damage and morphometric data may provide relevant insight about the changing
microenvironment promoted by the close proximity of a tumor. | |
| dc.publisher | ULTRASTRUCTURAL PATHOLOGY | |
| dc.relation | VOL. 42;2 | |
| dc.subject | Cancerization | |
| dc.subject | Colorectal | |
| dc.subject | Peritumoral | |
| dc.subject | Tumor | |
| dc.subject | Utrastructure | |
| dc.title | Ultrastructure of colorectal adenocarcinoma and peritumoral tissue in untreated patients | |
