dc.creator | Janaína Martins Bretas | |
dc.creator | Maria das Dores Graciano Silva | |
dc.creator | Mariana Martins Gonzaga do Nascimento | |
dc.date.accessioned | 2023-05-11T20:16:30Z | |
dc.date.accessioned | 2023-06-16T16:27:01Z | |
dc.date.available | 2023-05-11T20:16:30Z | |
dc.date.available | 2023-06-16T16:27:01Z | |
dc.date.created | 2023-05-11T20:16:30Z | |
dc.date.issued | 2017 | |
dc.identifier | http://dx.doi.org/10.14450/2318-9312.v29.e3.a2017.pp235-240 | |
dc.identifier | 2318-9312 | |
dc.identifier | http://hdl.handle.net/1843/53130 | |
dc.identifier | https://orcid.org/0000-0003-2183-4365 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/6682425 | |
dc.description.abstract | The objective of this study was to assess the implementation of adverse drug reactions (ADR) active surveillance strategies using computerized tools in a pharmacovigilance program of a large private hospital. The study was developed in three phases: I. implementation of the pharmacovigilance service (passive surveillance – intensified voluntary notification); II. active surveillance based on managerial reports of consumption of tracer drugs; III. active surveillance based on the content of forms that were filled out in the electronic system whenever a tracer drug was prescribed. All the ADR detected by the pharmacovigilance service for three and a half years (n = 542) were analyzed. The difference between the ADR/100 patients-day was analyzed by the comparison of two proportions, with a 5% significance level and power of 80%. The rate of ADR/100 patient-day identified in phase II and III (0.26 and 0.15, respectively), that is, after the implementation of computerized tools, was higher than the rate detected in phase I (0.10). The difference between the proportions was statistically significant. The majority of ADR identified presented moderate severity (69%), and an increase in this proportion was observed after the implementation of computerized tools. Regarding the causality assessment, 83.6% of the identified ADR was classified as “possible causality”. The implementation of active surveillance using computerized tools provided a statistically significant increase in the identification of ADR identification, reinforcing the need to intensify such pharmacovigilance strategies. | |
dc.publisher | Universidade Federal de Minas Gerais | |
dc.publisher | Brasil | |
dc.publisher | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS | |
dc.publisher | HCL - HOSPITAL DAS CLINICAS | |
dc.publisher | UFMG | |
dc.relation | Infarma: Ciências Farmacêuticas | |
dc.rights | Acesso Aberto | |
dc.subject | Farmacovigilância | |
dc.subject | Efeitos colaterais e reações adversas relacionados a medicamentos | |
dc.subject | Sistemas de notificação de reações adversas a medicamentos | |
dc.subject | Prescrição eletrônica | |
dc.title | Avaliação da implantação de busca ativa de reações adversas a medicamentos com auxílio de ferramentas informatizadas | |
dc.type | Artigo de Periódico | |