| dc.description.abstract | Introduction: Infections are the main complications in patients undergoing transplantation of
hematopoietic stem cell transplantation (HSCT). Objective: To highlight the major infectious
complications related to this type of transplant. Method: An integrative literature review was
performed using the Medical Literature Analysis and Retrieval System Online, in Portuguese,
English and Spanish. 75 articles were obtained and included 17. The inclusion criteria were:
papers discussing the issue in adults or children, hospitalized to perform transplantation and
after transplant. Exclusion criteria were: monographs, dissertations, books and publications
that were not available. Results: The main infections were described: clinical sepsis,
bloodstream infection associated with central venous catheters, bacterial and viral diarrhea,
fungemias, pneumonia, fungal infections, mucomicoses, mucositis, virus infection (herpes,
cytomegalovirus, rotavirus, H1N1) and toxoplasmosis. Risk factors for these infections,
neutropenia, transplant type, cell source, the use of prophylactic antibiotics, different
intensities of conditioning, graft versus host, high doses of corticosteroids. Conclusion: Most
publications demonstrated that bacterial infections are responsible for the infectious
complications in patients undergoing HSCT, followed by viruses, fungi and parasites.
Monitor the cellular immunity of these patients, reduce neutropenia period, avoid the
indiscriminate use of drugs, control infections, improve supportive care and avoid the use of
invasive procedures are important measures for the prevention of infectious complications
related to HSCT. | |
