Efecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimiento

dc.contributorWandurraga Sanchez, Edwin Antonio
dc.contributorLópez Gómez, Luis Ernesto
dc.contributorDíaz Posada, Néstor Andrés [0001753828]
dc.contributorWandurraga Sánchez, Edwin Antonio [0001475567]
dc.contributorLópez Gómez, Luis Ernesto [0001785761]
dc.contributorDíaz Posada, Néstor Andrés [0000-0002-3729-0043]
dc.contributorWandurraga Sánchez, Edwin Antonio [0000-0002-0529-2343]
dc.contributorLópez Gómez, Luis Ernesto [0000-0002-3666-2159]
dc.contributorAdriana Lucila Reyes González
dc.contributorWandurraga Sánchez, Edwin Antonio [edwin-antonio-wandurraga-sánchez]
dc.contributorLópez Gómez, Luis Ernesto [luis-ernesto-lópez-gómez]
dc.creatorDíaz Posada, Néstor Andrés
dc.date.accessioned2023-04-25T12:51:19Z
dc.date.accessioned2023-06-12T20:26:57Z
dc.date.available2023-04-25T12:51:19Z
dc.date.available2023-06-12T20:26:57Z
dc.date.created2023-04-25T12:51:19Z
dc.date.issued2023-04-24
dc.identifierhttp://hdl.handle.net/20.500.12749/19640
dc.identifierinstname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifierreponame:Repositorio Institucional UNAB
dc.identifierrepourl:https://repository.unab.edu.co
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6662764
dc.description.abstractIntroducción: La obesidad no es solo un problema estético, es una enfermedad que viene en aumento alcanzando una prevalencia en Colombia del 18% para el 2015 según la encuesta ENSIN, la cual incrementa el riesgo cardiovascular asociado a la resistencia a la insulina (RI) y componente proinflamatorio crónico asociado a la adiposidad. Se desea conocer el impacto de la cirugía bariátrica en la perdida de peso según la resistencia a la insulina medida por HOMA-IR en nuestra población. Metodología: Cohorte mediante análisis de base de datos secundarios-anonimizados, recolectados entre 2016-2021 en una institución de alta complejidad en la ciudad de Bucaramanga, Santander, Colombia que fueron llevados a Gastrectomía vertical (GV) o Bypass gástrico (BGYR) con seguimiento a un año. Resultados: Respecto a la obesidad se logró normalización del IMC en el 42% llevados a GV y 26% a BGYR. En cuanto al síndrome metabólico de 94 pacientes cumplían criterios IDF adaptados a nuestra población previo a la intervención quirúrgica 60% GV y 20% BGYR persistiendo en menos del 2% en cada grupo posterior a un año esta condición. La RI en el grupo de BGYR pasó del 79,7% al 11,3% y en GV pasó del 86,5% al 23%. Conclusiones: La cirugía bariátrica es una herramienta eficaz para disminuir la RI, siendo este efecto mayor en la BGYR. Adicionalmente se demostró remsión del síndrome metabólico en el 98% que tenían esta condición previa al procedimiento.
dc.languagespa
dc.publisherUniversidad Autónoma de Bucaramanga UNAB
dc.publisherFacultad Ciencias de la Salud
dc.publisherEspecialización en Medicina Interna
dc.relation1. Flegal KM, Carroll D, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA - J Am Med Assoc. 2012;307(5):491–7.
dc.relation2. Cirilo B. Epidemiological aspects about obesity in Latin America: challenges for the future. Medwave. 2012;12(01):e5289–e5289.
dc.relation3. Ministerio de Salud y Protección Social. Encuesta Nacional de la Situación Nutricional – ENSIN 2015 Objetivo. 2015;1–65.
dc.relation4. Taylor SI, Dons RF, Hernandez E, Roth J, Gorden P. Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Ann Intern Med. 1982;97(6):851–5.
dc.relation5. Dixon J, Zimmet P, Alberti K, Rubino F. Bariatric surgery: an IDF statement for obese Type 2 diabetes. Arq Bras Endocrinol Metabol. 2011;55(6):367–82.
dc.relation6. MacMahon S, Baigent C, Duffy S, Rodgers A, Tominaga S, Chambless L, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009 Mar;373(9669):1083.
dc.relation7. Jamialahmadi T, Reiner Ž, Alidadi M, Kroh M, Cardenia V, Xu S, et al. The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low-Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta-Analysis. Oxid Med Cell Longev. 2021;2021.
dc.relation8. Raúl Carrillo-Esper MJM-B. Tratamiento quirúrgico de la diabetes mellitus tipo 2 Surgical treatment of type 2 diabetes mellitus. Unidad Ter Intensiva Fund Clínica Médica Sur. 2014;219–30.
dc.relation9. Schauer PR, Burguera B, Ikramuddin S, Cottam D, Gourash W, Hamad G, et al. Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus. Ann Surg. 2003;238(4):467–85.
dc.relation10. Tohidi M, Ghasemi A, Hadaegh F, Derakhshan A, Chary A, Azizi F. Age- and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy Iranian adults: Tehran Lipid and Glucose Study. Clin Biochem. 2014;47(6):432–8.
dc.relation11. Cacho J, Sevillano J, De Castro J, Herrera E, Ramos MP. Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats. Am J Physiol - Endocrinol Metab. 2008;295(5):1269–76.
dc.relation12. Tratado “El estómago” Tomo 1. (n.d.). Retrieved December 4, 2022, from https://www.ascolcirugia.org/component/k2/item/118-estomagotomo1.html
dc.relation13. Tratado “El estómago” Tomo 1. (n.d.). Retrieved December 4, 2022, from https://www.ascolcirugia.org/component/k2/item/118-estomagotomo1.html
dc.relation14. Pataky Z, Bobbioni-Harsch E, Golay A. Open questions about metabolically normal obesity. Int J Obes. 2010;34:S18–23.
dc.relation15. Poulos SP, Hausman DB, Hausman GJ. The development and endocrine functions of adipose tissue. Mol Cell Endocrinol. 2010;323(1):20–34.
dc.relation16. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8(11):1288–95.
dc.relation17. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752–61.
dc.relation18. Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U. Insulin resistance and impaired adipogenesis. Trends Endocrinol Metab. 2015;26(4):193–200.
dc.relation19. Hocking S, Samocha-Bonet D, Milner KL, Greenfield JR, Chisholm DJ. Adiposity and insulin resistance in humans: The role of the different tissue and cellular lipid depots. Endocr Rev. 2013;34(4):463–500.
dc.relation20. Bikman BT, Summers SA. Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest. 2011;121(11):4222–30.
dc.relation21. Barazzoni R, Gortan Cappellari G, Ragni M, Nisoli E. Insulin resistance in obesity: an overview of fundamental alterations. Eat Weight Disord. 2018;23(2):149–57.
dc.relation22. Ann L Coker, Nalawansha, Dhanusha A. Pflum MK. 乳鼠心肌提取 HHS Public Access. Physiol Behav. 2017;176(5):139–48.
dc.relation23. Sethi JK, Vidal-Puig AJ. Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007;48(6):1253–62.
dc.relation24. Jesús TE, Eduardo VC, Alejandro C, Froylán RJ, Humberto B. diagnostic tool in Aguascalientes. 2015;73–85.
dc.relation25. Fargion S, Dongiovanni P, Guzzo A, Colombo S, Valenti L, Fracanzani AL. Iron and insulin resistance. Aliment Pharmacol Ther Suppl. 2005;22(2):61–3.
dc.relation26. Ruban A, Stoenchev K, Ashrafian H, Teare J. Current treatments for obesity. Clin Med J R Coll Physicians London. 2019;19(3):205–12.
dc.relation27. National Institute for Health and Care Excellence. Obesity: clinical assessment and management (QS127). Natl Inst Heal Care Excell. 2016;(August 2016):44.
dc.relation28. Sahebkar A, Simental-Mendía LE, Reiner Ž, Kovanen PT, Simental-Mendía M, Bianconi V, et al. Effect of orlistat on plasma lipids and body weight: A systematic review and meta-analysis of 33 randomized controlled trials. Pharmacol Res. 2017;122:53–65.
dc.relation29. Js T, J H, Mn B, L S. Xenical in the prevention of diabetes in obese subjects (XENDOS) study. Diabetes Care. 2004;27(1):155–61.
dc.relation30. Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344(7841):1–11.
dc.relation31. Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11–22.
dc.relation32. Jones B. Liraglutide and cardiovascular outcomes in type 2 diabetes. Ann Clin Biochem. 2016;53(6):712.
dc.relation33. Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376(9741):595–605.
dc.relation34. Bohula EA, Wiviott SD, McGuire DK, Inzucchi SE, Kuder J, Im K, et al. Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients. N Engl J Med. 2018;379(12):1107–17.
dc.relation35. Lonneman DJ, Rey JA, McKee BD. Phentermine/Topiramate extended-release capsules (Qsymia) for weight loss. P T. 2013;38(8).
dc.relation36. ACTUALIZACIÓN DE GUÍAS ACOCIB 2018 © 2016 DISTRIBUNA LTDA ISBN : Editores : César Ernesto Guevara P ., MD Rami Mikler L ., MD Corrección de estilo : Ligia Yamila Villarraga Peña Diseño y diagramación : Arley Bácares Tique Impreso en Colombia Printed in Co.
dc.relation37. Team TNLSTR. New England Journal. N Engl J Med. 2015; 352:687–96.
dc.relation38. Ballantyne GH, Farkas D, Laker S, Wasielewski A. Short-term changes in insulin resistance following weight loss surgery for morbid obesity: Laparoscopic adjustable gastric banding versus laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2006;16(9):1189–97.
dc.relation39. Ozmen MM, Guldogan CE, Gundogdu E. Changes in HOMA-IR index levels after bariatric surgery: Comparison of Single Anastomosis Duodenal Switch-proximal approach (SADS-p) and One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB). Int J Surg. 2020;78(8):36–41.
dc.relation40. Casas-Tapia C, Araujo-Castillo R V., Saavedra-Tafur L, Bert-Dulanto A, Piscoya A, Casas-Lucich A. Higher HOMA-IR Index Is Associated With Increased Excess Weight Loss in Patients With BMI ≥ 35 kg/m2 After Vertical Gastrectomy. Cirugía Española (English Ed. 2020;98(6):328–35.
dc.relation41. Liu D feng, Ma Z ye, Zhang C shun, Lin Q, Li M wen, Su K zhen, et al. The effects of bariatric surgery on dyslipidemia and insulin resistance in overweight patients with or without type 2 diabetes: a systematic review and network meta-analysis. Surg Obes Relat Dis. 2021;17(9):1655–72.
dc.relation42. Rao RS, Yanagisawa R, Kini S. Insulin resistance and bariatric surgery. Obes Rev. 2012;13(4):316–28.
dc.relation43. Zhu Y, Sun Z, Du Y, Xu G, Gong K, Zhu B, et al. Evaluation of insulin resistance improvement after laparoscopic sleeve gastrectomy or gastric bypass surgery with HOMA-IR. Biosci Trends. 2017;11(6):675–81.
dc.relation44. Stenberg E, Rask E, Szabo E, Näslund I, Ottosson J. The Effect of Laparoscopic Gastric Bypass Surgery on Insulin Resistance and Glycosylated Hemoglobin A1c: a 2-Year Follow-up Study. Obes Surg. 2020;30(9):3489–95.
dc.relation45. Angrisani L, Santonicola A, Iovino P, Ramos A, Shikora S, Kow L. Bariatric Surgery Survey 2018: Similarities and Disparities Among the 5 IFSO Chapters. Obes Surg [Internet]. 2021 May 12;31(5):1937–48. Available from: https://link.springer.com/10.1007/s11695-020-05207-7
dc.relation46. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. Journal of Clinical Investigation. 2006.
dc.relation47. Schinner S, Scherbaum WA, Bornstein SR, Barthel A. Molecular mechanisms of insulin resistance. Diabet Med [Internet]. 2005 Jun;22(6):674–82. Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2005.01566.x
dc.relation48. Benaiges D, Flores Le-Roux JA, Pedro-Botet J, Chillarón JJ, Renard M, Parri A, et al. Sleeve gastrectomy and Roux-en-Y gastric bypass are equally effective in correcting insulin resistance. Int J Surg [Internet]. 2013 May;11(4):309–13. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1743919113000393
dc.relation49. Christelle H, Thierry H, Aristotle RD, Alain B, Ralph P, Markus Z. Comparison of metabolic outcomes in patients undergoing laparoscopic roux-en-Y gastric bypass versus sleeve gastrectomy – a systematic review and meta-analysis of randomised controlled trials. Swiss Med Wkly. 2018;
dc.relation50. Bhandari M, Reddy M, Kosta S, Mathur W, Fobi M. Laparoscopic sleeve gastrectomy versus laparoscopic gastric bypass: A retrospective cohort study. Int J Surg. 2019;
dc.relation51. Trakhtenbroit MA, Leichman JG, Algahim MF, Miller CC, Moody FG, Lux TR, et al. Body Weight, Insulin Resistance, and Serum Adipokine Levels 2 Years after 2 Types of Bariatric Surgery. Am J Med [Internet]. 2009 May;122(5):435–42. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0002934308011856
dc.relation52. van Dielen FMH, Nijhuis J, Rensen SSM, Schaper NC, Wiebolt J, Koks A, et al. Early insulin sensitivity after restrictive bariatric surgery, inconsistency between HOMA-IR and steady-state plasma glucose levels. Surg Obes Relat Dis [Internet]. 2010 Jul;6(4):340–4. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1550728909007643
dc.relation53. Kahn BB, Flier JS. Obesity and insulin resistance. Journal of Clinical Investigation. 2000.
dc.relation54. Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem. 1998;
dc.relation55. Khalaf KI, Taegtmeyer H. Clues from Bariatric Surgery: Reversing Insulin Resistance to Heal the Heart. Curr Diab Rep [Internet]. 2013 Apr 26;13(2):245–51. Available from: http://link.springer.com/10.1007/s11892-013-0364-1
dc.relation56. Stenberg E, Thorell A. Insulin resistance in bariatric surgery. Current Opinion in Clinical Nutrition and Metabolic Care. 2020.
dc.relation57. Alamro N, Azhri AS, Almuqati A, Azzeh F, Azhar W, Qadhi A, et al. Effect of bariatric surgery on metabolic syndrome, Framingham risk scores and thyroid function during one-year follow-up: A Saudi retrospective study. Healthcare (Basel) [Internet]. 2022 [cited 2023 Feb 16];10(12):2530. Available from: https://pubmed.ncbi.nlm.nih.gov/36554054/
dc.relation58. Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep [Internet]. 2018 [cited 2023 Feb 16];20(2):12. Available from: https://pubmed.ncbi.nlm.nih.gov/29480368/
dc.relation59. Ji Y, Lee H, Kaura S, Yip J, Sun H, Guan L, et al. Effect of bariatric surgery on metabolic diseases and underlying mechanisms. Biomolecules [Internet]. 2021 [cited 2023 Feb 16];11(11). Available from: https://pubmed.ncbi.nlm.nih.gov/34827579/
dc.relation60. Batsis JA, Romero-Corral A, Collazo-Clavell ML, Sarr MG, Somers VK, Lopez-Jimenez F. Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study. Mayo Clin Proc [Internet]. 2008 [cited 2023 Feb 16];83(8):897–907. Available from: https://pubmed.ncbi.nlm.nih.gov/18674474/
dc.relation61. Giraldo L, Buendia R, Avendaño JR, Oyaga L, Morales A, Zambrano M, et al. Efectividad del bypass gástrico sobre factores de riesgo cardiovascular y obesidad. Rev Venez Endocrinol y Metab [Internet]. 2003;14(1):38–44. Available from: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S1690-31102016000100005&lng=es&nrm=iso&tlng=es
dc.relation62. Gil-Rojas Y, Garzón A, Lasalvia P, Hernández F, Castañeda-Cardona C, Rosselli D. Cost-Effectiveness of Bariatric Surgery Compared With Nonsurgical Treatment in People With Obesity and Comorbidity in Colombia. Value Heal Reg Issues [Internet]. 2019 Dec;20(40):79–85. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2212109919300500
dc.relationhttps://apolo.unab.edu.co/en/persons/edwin-antonio-wandurraga-s%C3%A1nchez
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightsAbierto (Texto Completo)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.titleEfecto de la cirugía bariátrica sobre la resistencia a la insulina en pacientes sin diabetes mellitus a un año de seguimiento


Este ítem pertenece a la siguiente institución