Antiproliferative and structure activity relationships of amaryllidaceae alkaloids

dc.creatorCedrón, Juan C.
dc.creatorRavelo, Ángel G.
dc.creatorLeón, Leticia G.
dc.creatorPadrón, José M.
dc.creatorEstévez-Braun, Ana
dc.date.accessioned2021-03-17T18:06:34Z
dc.date.available2021-03-17T18:06:34Z
dc.date.created2021-03-17T18:06:34Z
dc.date.issued2015-07-30
dc.identifier1420-3049
dc.identifierhttps://hdl.handle.net/20.500.12815/215
dc.identifierhttps://doi.org/10.3390/molecules200813854
dc.identifierMolecules
dc.description.abstractThe antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined. The best antiproliferative activities were achieved with alkaloids derived from pancracine (2), haemanthamine (6) and haemantidine (7). For each skeleton, some structure-activity relationships were outlined.
dc.languageeng
dc.publisherMDPI
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRepositorio Institucional UTEC
dc.sourceUniversidad de Ingeniería y Tecnología - UTEC
dc.subjectAmarylidaceae alkaloids
dc.subjectAntiproliferative activity
dc.subjectSAR
dc.titleAntiproliferative and structure activity relationships of amaryllidaceae alkaloids
dc.typeinfo:eu-repo/semantics/article


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