dc.creatorSeemann, Felicia
dc.creatorBaldassarre, Lauren A.
dc.creatorLlanos-Chea, Fiorella
dc.creatorGonzales, Ricardo A.
dc.creatorGrunseich, Karl
dc.creatorHu, Chenxi
dc.creatorSugeng, Lissa
dc.creatorMeadows, Judith
dc.creatorHeiberg, Einar
dc.creatorPeters, Dana C.
dc.date.accessioned2021-03-17T18:04:28Z
dc.date.available2021-03-17T18:04:28Z
dc.date.created2021-03-17T18:04:28Z
dc.date.issued2018-09-05
dc.identifier2051-817X
dc.identifierhttps://hdl.handle.net/20.500.12815/204
dc.identifierhttps://doi.org/10.14814/phy2.13828
dc.identifierPhysiological Reports
dc.description.abstractAtrial fibrosis can be estimated noninvasively by magnetic resonance imaging (MRI) using late gadolinium enhancement (LGE), but diastolic dysfunction is clinically assessed by transthoracic echocardiography (TTE), and rarely by MRI. This study aimed to evaluate well-established diastolic parameters using MRI, and validate them with TTE and left ventricular (LV) filling pressures, and to study the relationship between left atrial (LA) remodeling and parameters of diastolic function. The study retrospectively included 105 patients (53 ± 16 years, 39 females) who underwent 3D LGE MRI between 2012 and 2016. Medical charts were reviewed for the echocardiographic diastolic parameters E, A, and e′ by TTE, and pressure catheterizations. E and A were measured from in-plane phase-contrast cardiac MRI images, and e′ by feature-tracking, and validated with TTE. Interobserver and intraobserver variability was examined. Furthermore, LA volumes, function, and atrial LGE was correlated with diastolic parameters. Evaluation of e′ in MRI had strong agreement with TTE (r = 0.75, P < 0.0001), and low interobserver and intraobserver variability. E and A by TTE showed strong agreement to MRI (r = 0.77, P = 0.001; r = 0.73, P = 0.003, for E and A, respectively). Agreement between E/e′ by TTE and MRI was strong (r = 0.85, P = 0.0004), and E/e′ by TTE correlated moderately to invasive pressures (r = 0.59, P = 0.03). There was a strong relationship between LA LGE and pulmonary capillary wedge pressure (r = 0.81, P = 0.01). In conclusion, diastolic parameters can be measured with good reproducibility by cardiovascular MRI. LA LGE exhibited a strong relationship with pulmonary capillary wedge pressure, an indicator of diastolic function.
dc.languageeng
dc.publisherWiley
dc.publisherAmerican Physiological Society
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRepositorio Institucional UTEC
dc.sourceUniversidad de Ingeniería y Tecnología - UTEC
dc.subjectCardiovascular magnetic resonance imaging
dc.subjectDiastolic function
dc.subjectEchocardiography
dc.subjectLeft atrial late gadolinium enhancement
dc.subjectLeft ventricular filling pressure
dc.titleAssessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure
dc.typeinfo:eu-repo/semantics/article


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