| dc.creator | Pagán Vargas, Rafael Francisco | |
| dc.creator | Velev, Julian (Consejero) | |
| dc.date | 2015-12-08T14:33:50Z | |
| dc.date | 2015-12-08T14:33:50Z | |
| dc.date | 2015-12-08T14:33:50Z | |
| dc.date.accessioned | 2017-03-17T16:54:48Z | |
| dc.date.available | 2017-03-17T16:54:48Z | |
| dc.identifier | http://hdl.handle.net/10586 /564 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/647680 | |
| dc.description | In this work we study the emergence of mutational robustness in the evolution of several
example proteins and how robustness is related to underlying phenotype space. We
employ a Wright Fisher model where a population of proteins is randomly mutated and
selected for energy of folding with various selection models in the presence and absence
of genetic drift. Protein coordinates were obtained from the protein data bank. Our model
predicts that the fluctuations of mutational robustness are exponentially distributed and
that robustness is a consequence of a topological phase transition in genotype space. The
process that drives this transition is described by Bianconi-Barabási model for
preferential attachment. Additionally the emergence of error minimization is observed
along with this phase transition. | |
| dc.language | en | |
| dc.subject | Molecular evolution | |
| dc.subject | Mutational robustness | |
| dc.subject | Genotype space | |
| dc.subject | Proteins | |
| dc.subject | Networks | |
| dc.subject | Wright Fisher model | |
| dc.subject | Biophysics | |
| dc.subject | Evolutionary game theory | |
| dc.subject | Protein space | |
| dc.subject | Phenotype space | |
| dc.title | Dynamics of Protein Networks Exhibiting Complex Behavior | |
| dc.type | Tesis | |
