New animal models of neurocysticercosis can help understand epileptogenesis in neuroinfection

Abstract

Neurocysticercosis (NCC), defined as an infection of the central nervous system (CNS) by the cystic larval stage of the pork tapeworm Taenia solium, remains a major challenge in public health mainly due to associated neurological morbidity (Garcia et al., 2020; Bustos J. et al., 2021). This infection is endemic in most of the developing world including Central and South America, Sub-Saharan Africa, and large regions of Asia including India, China, and Southeast Asia (Ndimubanzi et al., 2010; Garcia et al., 2020; Bustos J. et al., 2021). NCC is also increasingly diagnosed in non-endemic countries and industrialized countries due to immigration and travel from endemic zones (O'Neal et al., 2011; Gabriël et al., 2015; O'Neal and Flecker, 2015)...