In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii

dc.contributorEunice Romero
dc.contributorANGELICA LUNA NOPHAL
dc.contributorJOHANNA BERNALDEZ SARABIA
dc.contributorLILIANA NOEMI SANCHEZ CAMPOS
dc.contributorALEXEI FEDOROVISH LICEA NAVARRO
dc.contributorJORGE MORALES MONTOR
dc.contributorSAE MUÑIZ HERNANDEZ
dc.creatorMARCO ANTONIO DE LEON NAVA
dc.date2016
dc.date.accessioned2023-03-16T14:29:36Z
dc.date.available2023-03-16T14:29:36Z
dc.identifierhttp://cicese.repositorioinstitucional.mx/jspui/handle/1007/1726
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6229762
dc.description"Toxins that are secreted by cone snails are small peptides that are used to treat several diseases. However, their effects on parasites with human and veterinary significance are unknown. Toxoplasma gondii is an opportunistic parasite that affects approximately 30% of the world’s population and can be lethal in immunologically compromised individuals. The conventional treatment for this parasitic infection has remained the same since the 1950s, and its efficacy is limited to the acute phase of infection. These findings have necessitated the search for new drugs that specifically target T. gondii. We examined the effects of the synthetic toxin cal14.1a (s-cal14.1a) from C. californicus on the tachyzoite form of T. gondii. Our results indicate that, at micromolar concentrations, s-cal14.1a lowers viability and inhibits host cell invasion (by 50% and 61%, respectively) on exposure to extracellular parasites. Further, intracellular replication decreased significantly while viability of the host cell was unaffected. Our study is the first report on the antiparasitic activity of a synthetic toxin of C. californicus"
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI AG
dc.relationinfo:eu-repo/semantics/altIdentifier/DOI/http://dx.doi.org/10.3390/md14040066
dc.relationcitation:De León Nava,M.A.,Romero Núñez,E.,Luna Nophal,A.,Bernáldez Sarabia,J.,Sánchez Campos,L.,Licea Navarro,A.F.,Morales Montor,J.,Muñiz Hernández,S.2016.In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii.Marine Drugs,14(4),1-12.doi:10.3390/md14040066
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceMarine Drugs, Vol. 14, No. 4, Págs. 1-12
dc.subjectinfo:eu-repo/classification/Autor/Conotoxin, Conus californicus, Toxoplasma gondii, Antiparasitic toxin, Parasite replication, Host-cell invasion
dc.subjectinfo:eu-repo/classification/cti/2
dc.subjectinfo:eu-repo/classification/cti/2
dc.titleIn Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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