The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis

dc.creatorBlanco, Federico Carlos
dc.creatorGarcia, Elizabeth Andrea
dc.creatorAagaard, Claus
dc.creatorBigi, Fabiana
dc.date.accessioned2021-12-15T16:23:28Z
dc.date.accessioned2023-03-15T14:12:36Z
dc.date.available2021-12-15T16:23:28Z
dc.date.available2023-03-15T14:12:36Z
dc.date.created2021-12-15T16:23:28Z
dc.date.issued2021-05
dc.identifier0034-5288
dc.identifierhttps://doi.org/10.1016/j.rvsc.2021.04.014
dc.identifierhttp://hdl.handle.net/20.500.12123/10917
dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S0034528821001132
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6213877
dc.description.abstractH65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.sourceResearch in Veterinary Science 136 : 595-597 (May 2021)
dc.subjectMycobacterium bovis
dc.subjectVacuna
dc.subjectControl de Enfermedades
dc.subjectInfección por Mycobacterium Bovis
dc.subjectVaccines
dc.subjectDisease Control
dc.subjectMycobacterium Bovis Infections
dc.titleThe subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion


Este ítem pertenece a la siguiente institución