dc.creatorCarossino, Mariano
dc.creatorThiry, Etienne
dc.creatorGrandière, Ana de la
dc.creatorBarrandeguy, Maria Edith
dc.date.accessioned2019-01-25T17:12:50Z
dc.date.accessioned2023-03-15T13:58:09Z
dc.date.available2019-01-25T17:12:50Z
dc.date.available2023-03-15T13:58:09Z
dc.date.created2019-01-25T17:12:50Z
dc.date.issued2014-01-09
dc.identifier0264-410X
dc.identifierhttps://doi.org/10.1016/j.vaccine.2013.11.071
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0264410X13016332
dc.identifierhttp://hdl.handle.net/20.500.12123/4336
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6207538
dc.description.abstractThe current production of inactivated vaccines for the prevention of equine alphavirus encephalitides caused by Eastern, Western and Venezuelan Equine Encephalitis viruses (EEEV, WEEV, VEEV) involves the manipulation of large quantities of infectious viral particles under biosafety level 3 containment laboratories with the potential risk of transmission to the operators. Moreover, these vaccines are not capable of inducing a long-lasting immunity. Modified live vaccines, which were also attempted, maintain residual virulence and neurotropism, causing disease in both horses and humans. Therefore, the production of an efficacious second generation vaccine which could be used in the prevention of alphavirus infection without the need to manipulate infectious viral particles under high biocontainment conditions could be of great benefit for the worldwide horse industry. Furthermore, equine alphaviruses are considered as biological threat agents. Subunit, chimeric, gene-deleted live mutants, DNA and adenovirus-vectored alphavirus vaccines have been evaluated; such approaches are reviewed in this work. Climate changes, together with modifications in bird and vector ecology, are leading to the arise of emerging pathogens in new geographical locations, and these zoonotic New World arboviruses are gaining concern. Novel vaccine development does show a promising future for prevention of these infections in both horses and humans.
dc.languageeng
dc.publisherElsevier
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceVaccine 32 (3) : 311-319 (January 2014)
dc.subjectCaballos
dc.subjectEnfermedades de los Animales
dc.subjectAlphavirus
dc.subjectVirus de la Encéfalo Mielitis Equina
dc.subjectVacunación
dc.subjectHorses
dc.subjectAnimal Diseases
dc.subjectEquine Encephalomyelitis Virus
dc.subjectVaccination
dc.titleNovel vaccination approaches against equine alphavirus encephalitides
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución