dc.creatorRegiart, Daniel Matias Gaston
dc.creatorPereira, Sirley Vanesa
dc.creatorSpotorno, Viviana Graciela
dc.creatorBertolino, Franco Adrián
dc.creatorRaba, Julio
dc.date.accessioned2018-09-12T15:29:58Z
dc.date.accessioned2023-03-15T13:56:08Z
dc.date.available2018-09-12T15:29:58Z
dc.date.available2023-03-15T13:56:08Z
dc.date.created2018-09-12T15:29:58Z
dc.date.issued2013-11
dc.identifier0925-4005
dc.identifierhttps://doi.org/10.1016/j.snb.2013.07.117
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S092540051300943X
dc.identifierhttp://hdl.handle.net/20.500.12123/3344
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6206591
dc.description.abstractA sensitive electrochemical sensor for clenbuterol (CL) determination in bovine urine samples was designed. This drug was originally developed for the treatment of respiratory pathologies. However, in the livestock industry, CL has been used as growth promoter because it stimulates the muscle growth and lipid degradation. The drug residues accumulated in animal tissues represent a potential risk for the human health. Subsequently, the development of a fast and simple method for the CL quantification employed to detect its abuse in livestock production is an attractive analytical challenge. The proposed method was based on the use of a screen printed carbon electrode (SPCE) modified with multiwall carbon nanotubes (MWCNTs) in a matrix of chitosan (CH) on gold nanoparticles (AuNPs) previously incorporated by electrodeposition process. The MWCNTs-CH/AuNPs/SPCE was characterized by cyclic voltammetry, X-ray diffraction and scan electron microscopy. With the aim to carry out the CL determination, a pre-concentration procedure was required. For this purpose, we employed anti-CL antibodies immobilized on magnetic microparticles (MPs) as bioaffinity support to capture the drug present in the sample. This support was exposed to a desorption process. Later, the electrochemical detection by square wave voltammetry (OSWV) was performed. The sensor exhibited excellent performances with a linear response range in concentrations from 0.01 to 6 ng mL−1. The detection and quantification limits obtained were 0.003 and 0.01 ng mL−1, respectively with an analysis time of 19 min and a R.S.D. below 5.8%. As a conclusion, we can claim that the results obtained by the proposed sensor were successful.
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceSensors and Actuators B: Chemical 188 : 1241-1249 (November 2013)
dc.subjectSensores
dc.subjectClenbuterol
dc.subjectMedicamentos Neurotrópicos
dc.subjectGanado
dc.subjectNanotecnología
dc.subjectInocuidad Alimentaria
dc.subjectSensors
dc.subjectNeurotropic Drugs
dc.subjectLivestock
dc.subjectNanotechnology
dc.subjectFood Safety
dc.subjectAnabolics
dc.subjectAnabólicos
dc.titleNanostructured voltammetric sensor for ultra-trace anabolic drug determination in food safety field
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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