Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

dc.creatorSilva Carvalho, Rosimeire
dc.creatorGaspar, Matheus Z.
dc.creatorQuadros, Luiz H. B.
dc.creatorLobo, Luís G. G.
dc.creatorGiuffrida, Rogério
dc.creatorSantarém, Cecília L.
dc.creatorSilva, Elisangela O.
dc.creatorGerez, Juliana Rubira
dc.creatorSilva, Nelson J.
dc.creatorHyslop, Stephen
dc.creatorLomonte, Bruno
dc.creatorFloriano, Rafael Stuani
dc.date.accessioned2023-01-05T18:54:03Z
dc.date.accessioned2023-03-13T12:46:25Z
dc.date.available2023-01-05T18:54:03Z
dc.date.available2023-03-13T12:46:25Z
dc.date.created2023-01-05T18:54:03Z
dc.date.issued2022
dc.identifierhttps://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihub
dc.identifier0041-0101
dc.identifierhttps://hdl.handle.net/10669/88017
dc.identifierdoi.org/10.1016/j.toxicon.2022.04.014
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/6118811
dc.description.abstractIn this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
dc.languageeng
dc.sourceToxicon 213 (2022), 99-104
dc.subjectMicrurus
dc.subjectvarespladib
dc.subjectSUSTANCIA PELIGROSA
dc.subjectSnake venom
dc.titlePartial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats
dc.typeartículo científico


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