Articulo Revista Indexada
Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
Registro en:
Roc L, de Mendoza C, Fernández-Alonso M, et al. Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals. Therapeutic Advances in Infectious Disease. 2019;6. doi:10.1177/2049936119868028
2049-937X
Autor
Roc, Lourdes
Mendoza, Carmen de
Fernández-Alonso, Miriam
Reina, Gabriel
Soriano, Vicente
Rodriguez, C.
...et al.
Corral, Octavio Jorge
Gómez-Gallego, Felix
Institución
Resumen
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor–recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.