dc.contributor | Universidade Federal de São Carlos (UFSCar) | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Neuroscience and Behavior Institute - IneC | |
dc.date.accessioned | 2022-05-01T06:31:27Z | |
dc.date.accessioned | 2022-12-20T03:38:56Z | |
dc.date.available | 2022-05-01T06:31:27Z | |
dc.date.available | 2022-12-20T03:38:56Z | |
dc.date.created | 2022-05-01T06:31:27Z | |
dc.date.issued | 2021-01-01 | |
dc.identifier | Social Neuroscience, v. 16, n. 5, p. 534-548, 2021. | |
dc.identifier | 1747-0927 | |
dc.identifier | 1747-0919 | |
dc.identifier | http://hdl.handle.net/11449/233303 | |
dc.identifier | 10.1080/17470919.2021.1954083 | |
dc.identifier | 2-s2.0-85111143581 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5413402 | |
dc.description.abstract | Cohabitation with a partner undergoing chronic pain induces pain hypersensitivity. Among a lot of other neurochemical pathways, the serotonin (5-HT) role, specifically the 5-HT3 receptor (5-HT3R), in the amygdala has never been evaluated in this model. Here we studied the effects of the amygdala’s chemical inhibition, its neuronal activation pattern, and 5-HT, 5-HIAA, and 5-HT turnover within the amygdala. Furthermore, the systemic and intra-amygdala 5-HT3R activation and blockade in mice that cohabited with a conspecific subjected to chronic constriction injury were investigated. Male Swiss mice were housed in partners for 28 days. The dyads were divided into two groups on the 14th day: cagemate nerve constriction (CNC) and cagemate sham (CS). On the 24th day, cagemates underwent a stereotaxic surgery (when necessary) and, on the 28th day, they were evaluated on the writhing test. The amygdala inactivation promotes pain-hypersensitivity behaviors in groups and dyads; cohabitation with a partner with chronic pain did not change FosB-labeled cells in the amygdala’s nucleus and increases 5-HT turnover in cagemates. Systemic and intra-amygdala 5-HT3R activation attenuated and enhanced the number of writhes, respectively. In contrast, 5-HT3R blockade reduced hypersensitivity pain response. Results suggest the involvement of amygdala serotonergic signaling via 5-HT3R in empathy-like behavior. | |
dc.language | eng | |
dc.relation | Social Neuroscience | |
dc.source | Scopus | |
dc.subject | 5-HT3 receptors | |
dc.subject | amygdala | |
dc.subject | Empathy | |
dc.subject | pain hypersensitivity 22 July 2021 | |
dc.subject | serotonin | |
dc.title | 5-HT3 receptor within the amygdaloid complex modulates pain hypersensitivity induced by empathy model of cohabitation with a partner in chronic pain condition in mice | |
dc.type | Artículos de revistas | |