Potentiometric determination of alendronate in pharmaceutical formulations

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:47:20Z
dc.date.accessioned2022-12-20T03:19:52Z
dc.date.available2022-04-29T08:47:20Z
dc.date.available2022-12-20T03:19:52Z
dc.date.created2022-04-29T08:47:20Z
dc.date.issued2004-12-01
dc.identifierChemia Analityczna, v. 49, n. 3, p. 351-357, 2004.
dc.identifier0009-2223
dc.identifierhttp://hdl.handle.net/11449/231758
dc.identifier2-s2.0-19544366456
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5411892
dc.description.abstractA simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 μg mL-1. In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.
dc.languageeng
dc.relationChemia Analityczna
dc.sourceScopus
dc.subjectAlendronate
dc.subjectPharmaceutical formulations
dc.subjectPotentiometric determination
dc.titlePotentiometric determination of alendronate in pharmaceutical formulations
dc.typeArtículos de revistas


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