dc.contributor | Universidade Federal do Ceará | |
dc.contributor | Hospital Universitário Walter Cantídio | |
dc.contributor | Hospital Geral de Fortaleza | |
dc.contributor | Hospital do Rim | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Hospital Israelita Albert Einstein | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Santa Casa de Misericórdia de Porto Alegre | |
dc.contributor | Faculdade de Medicina de São José do Rio Preto (FAMERP) | |
dc.contributor | Universidade Federal do Maranhão | |
dc.contributor | Universidade Federal do Rio Grande do Sul | |
dc.contributor | Hospital Universitário Onofre Lopes (HOUL) | |
dc.contributor | Hospital Santa Isabel | |
dc.contributor | Santa Casa de Misericórdia de Juiz de Fora | |
dc.contributor | Hospital de Base do Distrito Federal | |
dc.contributor | Hospital Municipal São José (HMSJ) | |
dc.contributor | Hospital Beneficência Portuguesa de São Paulo (BP) | |
dc.contributor | Universidade de São Paulo (USP) | |
dc.contributor | Universidade de Brasília (UnB) | |
dc.contributor | Hospital São Francisco na Providência de Deus | |
dc.date.accessioned | 2022-04-29T08:46:37Z | |
dc.date.accessioned | 2022-12-20T03:18:13Z | |
dc.date.available | 2022-04-29T08:46:37Z | |
dc.date.available | 2022-12-20T03:18:13Z | |
dc.date.created | 2022-04-29T08:46:37Z | |
dc.date.issued | 2022-02-01 | |
dc.identifier | Transplant International, v. 36. | |
dc.identifier | 1432-2277 | |
dc.identifier | 0934-0874 | |
dc.identifier | http://hdl.handle.net/11449/231620 | |
dc.identifier | 10.3389/ti.2022.10205 | |
dc.identifier | 2-s2.0-85124897556 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5411754 | |
dc.description.abstract | Data from the general population suggest that fatality rates declined during the course of the pandemic. This analysis, using data extracted from the Brazilian Kidney Transplant COVID-19 Registry, seeks to determine fatality rates over time since the index case on March 3rd, 2020. Data from hospitalized patients with RT-PCR positive SARS-CoV-2 infection from March to August 2020 (35 sites, 878 patients) were compared using trend tests according to quartiles (Q1: <72 days; Q2: 72–104 days; Q3: 105–140 days; Q4: >140 days after the index case). The 28-day fatality decreased from 29.5% (Q1) to 18.8% (Q4) (pfor-trend = 0.004). In multivariable analysis, patients diagnosed in Q4 showed a 35% reduced risk of death. The trend of reducing fatality was associated with a lower number of comorbidities (20.7–10.6%, pfor-trend = 0.002), younger age (55–53 years, pfor-trend = 0.062), and better baseline renal function (43.6–47.7 ml/min/1.73 m2, pfor-trend = 0.060), and were confirmed by multivariable analysis. The proportion of patients presenting dyspnea (pfor-trend = 0.001) and hypoxemia (pfor-trend < 0.001) at diagnosis, and requiring intensive care was also found reduced (pfor-trend = 0.038). Despite possible confounding variables and time-dependent sampling differences, we conclude that COVID-19-associated fatality decreased over time. Differences in demographics, clinical presentation, and treatment options might be involved. | |
dc.language | eng | |
dc.relation | Transplant International | |
dc.source | Scopus | |
dc.subject | coronavirus | |
dc.subject | Covid-19 | |
dc.subject | kidney transplant | |
dc.subject | renal transplantation | |
dc.subject | Sars-CoV-2 | |
dc.title | Temporal Reduction in COVID-19-Associated Fatality Among Kidney Transplant Recipients: The Brazilian COVID-19 Registry Cohort Study | |
dc.type | Artículos de revistas | |