dc.contributor | Laboratory of Immunogenetics | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.contributor | Hospital de Base of the Regional Medical Faculty Foundation (HB-FUNFARME) | |
dc.contributor | Visum Clinic | |
dc.date.accessioned | 2022-04-29T08:45:55Z | |
dc.date.accessioned | 2022-12-20T03:16:54Z | |
dc.date.available | 2022-04-29T08:45:55Z | |
dc.date.available | 2022-12-20T03:16:54Z | |
dc.date.created | 2022-04-29T08:45:55Z | |
dc.date.issued | 2021-01-01 | |
dc.identifier | Molecular Biology Reports. | |
dc.identifier | 1573-4978 | |
dc.identifier | 0301-4851 | |
dc.identifier | http://hdl.handle.net/11449/231514 | |
dc.identifier | 10.1007/s11033-021-06708-z | |
dc.identifier | 2-s2.0-85115372217 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5411648 | |
dc.description.abstract | Background: Until a few years ago, keratoconus was defined as a noninflammatory degenerative disease. However, recent studies have shown that the altered balance between inflammatory cytokines, proteases, and protease inhibitors, as well as free radicals and oxidants, have a crucial role in the pathogenesis of this disease. The aim of this study is to investigate whether interleukin 17 A G197A (rs2275913) and interleukin 17 F T7488C (rs763780) polymorphisms are associated with keratoconus in patients from a population of the northwestern region of the State of São Paulo, Brazil. Methods and Results: 35 patients and 61 controls were enrolled. Genotyping of interleukin 17 A G197A and interleukin 17 F T7488C polymorphisms was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Statistical analyses were conducted using the chi-square test, and an odds ratio with a 95% confidence interval was also calculated to evaluate the association between polymorphisms and disease. Evaluating interleukin 17 F T7488C, we found that the TT genotype is associated as a risk factor for keratoconus (P = 0.04; OR = 3.01; CI 1.11–8.14). As for evaluating interleukin 17 A G197A, the allele and genotype frequencies between patients and controls were compared and no statistically significant differences were found. Conclusions: Our data showed that the interleukin 17 F T7488C polymorphisms may exert an influence in keratoconus. | |
dc.language | eng | |
dc.relation | Molecular Biology Reports | |
dc.source | Scopus | |
dc.subject | Cytokines | |
dc.subject | Ectasia | |
dc.subject | Genetic polymorphisms | |
dc.subject | IL17 genotypes | |
dc.subject | Interleukins | |
dc.subject | Keratoconus | |
dc.title | Influence of interleukin 17 A and 17 F polymorphisms in keratoconus | |
dc.type | Artículos de revistas | |