dc.contributor | São Paulo Federal University | |
dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-29T08:43:44Z | |
dc.date.accessioned | 2022-12-20T03:12:06Z | |
dc.date.available | 2022-04-29T08:43:44Z | |
dc.date.available | 2022-12-20T03:12:06Z | |
dc.date.created | 2022-04-29T08:43:44Z | |
dc.date.issued | 2008-08-01 | |
dc.identifier | American Journal of Reproductive Immunology, v. 60, n. 2, p. 172-178, 2008. | |
dc.identifier | 1046-7408 | |
dc.identifier | 1600-0897 | |
dc.identifier | http://hdl.handle.net/11449/231115 | |
dc.identifier | 10.1111/j.1600-0897.2008.00609.x | |
dc.identifier | 2-s2.0-47949084045 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/5411249 | |
dc.description.abstract | Problem: Placental apoptosis-associated protein imbalance might contribute to the pathogenesis of pre- and post-term birth. Therefore, we evaluated the expression and distribution of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) molecules in term, pre-term and post-term placentas. Method of Study: Placental samples were collected from women with term (n = 25), pre-term (n = 7) and post-term (n = 10) deliveries. The expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens. Results: The pattern of immunostaining for Bcl-2 and Bax was the same in all samples, but not the intensity. The Bax/Bcl-2 ratio was higher in both pre-term and post-term placental samples compared with term placentas as a result of intense reactivity for the pro-apoptotic factor, Bax in pre-term and post-term placentas and, for Bcl-2 decrease in pre-term placentas. Conclusion: These findings suggest that different unbalance mechanisms in placental apoptotic-associated protein expressions may be involved in the physiopathology of pre-term and post-term births. © 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. | |
dc.language | eng | |
dc.relation | American Journal of Reproductive Immunology | |
dc.source | Scopus | |
dc.subject | Apoptosis | |
dc.subject | Parturition | |
dc.subject | Placenta | |
dc.subject | Post-term birth | |
dc.subject | Premature labor | |
dc.title | Bcl-2 and bax Expressions in pre-term, term and post-term placentas | |
dc.type | Artículos de revistas | |