dc.contributorUniversidade Estadual Paulista (UNESP)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorFederal University of Espirito Santo (UFES)
dc.date.accessioned2022-04-29T08:30:18Z
dc.date.accessioned2022-12-20T02:46:57Z
dc.date.available2022-04-29T08:30:18Z
dc.date.available2022-12-20T02:46:57Z
dc.date.created2022-04-29T08:30:18Z
dc.date.issued2021-07-15
dc.identifierInternational Journal of Pharmaceutics, v. 604.
dc.identifier1873-3476
dc.identifier0378-5173
dc.identifierhttp://hdl.handle.net/11449/229085
dc.identifier10.1016/j.ijpharm.2021.120756
dc.identifier2-s2.0-85109150321
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/5409219
dc.description.abstractOne of the challenges to the success of veterinary pharmacotherapy is the limited number of drugs and dosage forms available exclusively to this market, due to the interspecies variability of animals, such as anatomy, physiology, pharmacokinetics, and pharmacodynamics. For this reason, studies in this area have become a highlight, since they are still scarce in comparison with those on human drug use. To overcome many limitations related to the bioavailability, efficacy, and safety of pharmacotherapy in animals, especially livestock and domestic animals, polymers-based drug delivery systems are promising tools if they guarantee greater selectivity and less toxicity in dosage forms. In addition, these tools may be developed according to the great interspecies variability. To contribute to these discussions, this paper provides an updated review of the major polymer-based drug delivery systems projected for veterinary use. Traditional and innovative drug delivery systems based on polymers are presented, with an emphasis on films, microparticles, micelles, nanogels, nanoparticles, tablets, implants and hydrogel-based drug delivery systems. We discuss important concepts for the veterinarian about the mechanisms of drug release and, for the pharmacist, the advantages in the development of pharmaceutical forms for the animal population. Finally, challenges and opportunities are presented in the field of pharmaceutical dosage forms for veterinary use in response to the interests of the pharmaceutical industry.
dc.languageeng
dc.relationInternational Journal of Pharmaceutics
dc.sourceScopus
dc.subjectDrug delivery systems
dc.subjectImmediate-release
dc.subjectModified-release
dc.subjectPolymer
dc.subjectVeterinary pharmaceutical products
dc.titlePolymeric-based drug delivery systems for veterinary use: State of the art
dc.typeOtros


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